Effects of Neuromuscular Blockade Level and Intra-abdominal Pressure on Surgical Conditions and Cardiopulmonary Responses During Laparoscopic Colon Surgery With the Trendelenburg Position

The purpose of this study is to find out the effect of low abdominal pressure vs. standard abdominal pressure on the cardiac and respiratory function of the patients undergoing laparoscopic colon surgery in Trendelenberg position. It was also designed to evaluate the effect of the degree of neuromuscular blockade on the surgical condition of the patients undergoing laparoscopic colon surgery in Trendelenberg position.

Inclusion Criteria:

• Patients scheduled for laparoscopic colon surgery under Trendelenberg position

Exclusion Criteria:

• ASA classification IV
• Unable to make a written, informed consent
• Allergic to neuromuscular blocking agents, anesthetics, opioids
• Patients with neuromuscular disease
• Hepatic failure
• Renal failure
• History of malignant hyperthermia
• Morbid obesity with BMI>35 kg/m2
• Patients enrolled in another clinical trials