Duration of Continuous Positive Airway Pressure and Pulmonary Function Testing in Preterm Infants

Duration of Continuous Positive Airway Pressure and Pulmonary Function Testing in Preterm Infants

The primary aim of this study is to quantify and compare changes in lung volumes (as measured by functional residual capacity) in premature infants stable on continuous positive airway pressure (CPAP), and then randomized to two additional weeks of CPAP and room air versus room air alone. We hypothesize that infants randomized to additional CPAP will demonstrate an increased functional residual capacity (at the end of the two week study period and prior to discharge) compared to those randomized to room air.

Inclusion Criteria:

• Gestational age at birth <33 weeks
• Required CPAP for a minimum of 24 hours for respiratory distress
• Patient on CPAP and room air at time of randomization

Exclusion Criteria:

• Complex congenital heart disease other than patent ductus arteriosus or atrial septal defect
• Major malformations or chromosomal anomalies
• Multiple gestation greater than twins
• Culture proven sepsis or unstable at time of randomization