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| Name | Class |
|---|---|
| German Center for Neurodegenerative Diseases (DZNE) | OTHER |
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This study aims to proof the efficacy of a cognitive rehabilitation program for patients with mild dementia in Alzheimers Disease with respect to activities of daily living.
This prospective randomized, single blind intervention study aims to proof a cognitive rehabilitation program for patients with mild dementia in Alzheimers Disease (AD). The investigators modified a manualized and established German behavioural therapy program (KORDIAL) to use in a group context. The respective modules contain multimodal and multiprofessional approaches to improve capabilities relevant to activities of daily living (external memory support, compensation strategies, training of everyday competence, communication training). The intervention group receives this therapy for 12 weeks. Age and gender matched participants with AD serve as active control sample receiving a standardized cognitive training in the domesticity. The primary outcome are measurements of skills in activities of daily living prior the intervention as well as at the end of the intervention (after 3 months) and after 6 months (Follow up).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cognitive Rehabilitation | Experimental | cognitive rehabilitation for 12 weeks |
|
| Cognitive Training | Active Comparator | standardized cognitive training in the domesticity |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| cognitive rehabilitation | Behavioral |
| ||
| standardized cognitive training |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in activities of daily living measured by a test for action regulation and planning skills (HOTAP) to the end of intervention and to follow-up (6 months later) | prior intervention, after intervention (3 months), after 6 months | |
| Change from baseline in activities of daily living measured by an ADL-scale (Bayer-ADL) to the end of intervention and to follow-up (6 months later) | prior intervention, after intervention (3 months), after 6 months | |
| Change from baseline in behavioural memory abilities measured by a behavioural memory test (RBMT) to the end of intervention and to follow-up (6 months later) | prior intervention, after intervention (3 months), after 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in general cognitive state measured by the Consortium to Establish a Registry for Alzheimer´s Disease (CERAD) to the end of intervention and to follow-up (6 months later) | prior intervention, after intervention (3 months), after 6 months | |
| Change from baseline in structural and functional connectivity of the brain measured by MRI to the end of intervention and to follow-up (6 months later) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Elisabeth Kasper | Contact | +49 0381 4949618 | elisabeth.kasper@med.uni-rostock.de | |
| Yvonne Schmidt | Contact | +49 0381 4949471 | yvonne.schmidt@dzne.de |
| Name | Affiliation | Role |
|---|---|---|
| Stefan Teipel, Prof. | Department of Psychosomatic Medicine, University of Rostock, Rostock, Germany | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Psychosomatic Medicine, University of Rostock | Recruiting | Rostock | 18147 | Germany |
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| ID | Term |
|---|---|
| D000544 | Alzheimer Disease |
| ID | Term |
|---|---|
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D000091942 | Cognitive Training |
| ID | Term |
|---|---|
| D000066530 | Neurological Rehabilitation |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
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| Behavioral |
|
| prior intervention, after intervention (3 months), after 6 months |
| Change from baseline in depression and quality of life measured by two scales (GDS, DEMQoL) to the end of intervention and to follow-up (6 months later) | prior intervention, after intervention (3 months), after 6 months |
| D024801 |
| Tauopathies |
| D019636 | Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D005791 |
| Patient Care |
| D013812 | Therapeutics |
| D006296 | Health Services |
| D005159 | Health Care Facilities Workforce and Services |