To determine:

1. The safety of Vigam® Liquid in patients with primary or secondary antibody deficiency (PAD or SAD).
2. The efficacy of Vigam® Liquid in patients with primary or secondary antibody deficiency.
3. The half-life of Vigam® Liquid after 4 months of treatment.
4. The subclass and total gammaglobulin concentrations after each infusion of Vigam® Liquid.

Inclusion Criteria:

• Adults (18-80 years) with PAD or SAD
• With a low serum IgG (<6 g/l) and a history of recurrent infections
• Requiring and eligible for polyvalent intravenous immunoglobulin (IVIG) replacement therapy
• Non-reactive for HBsAg and with an alanine aminotransferase (ALT) level less than twice upper limit of normal prior to entry into the trial

Exclusion Criteria:

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