In this trial, patients with cancer in the upper gastrointestinal canal who are going to receive first line palliative chemotherapy and patients with colorectal cancer who are going to receive second line palliative chemotherapy will be included. Participating patients will be randomized between early contact with a palliative care unit, or contact with a palliative care unit when needed. The objectives with the trial is to investigate if an early establishment with a palliative care unit will have a positive impact on the patients quality of life, this also applies for the nearest relative, survival, and if a difference in numbers of chemotherapy cycles can be detected.

Inclusion Criteria:

• Patients with tumor in upper gastrointestinal canal, who is going to start treatment with first line palliative chemotherapy
• Patients with colorectal cancer, who is going to start treatment with second line palliative chemotherapy
• Signed written informed concent

Exclusion Criteria:

• Patients with neuroendocrine tumor
• Patients with already ongoing chemotherapy
• Patients with already established contact with palliative care unit

Patients with tumor in esophagus, stomach, pancreas liver-biliary passage receiving first line palliative chemotherapy, or patients with colorectal cancer receiving second line palliative chemotherapy.