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There is an association between intracranial arterial stenosis and ischemic stroke in young adults. The aim of this study is to evaluate the prevalence of intracranial arterial stenosis in asymptomatic regular resin of cannabis users in comparison with control subjects.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cannabis users | Experimental | Cerebral MRI and MRA |
|
| healthy volunteers | Active Comparator | Cerebral MRI and MRA |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cerebral MRI and MRA | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Presence of intracranial arterial stenosis on cerebral MRA | Rate on cerebral MRA the presence of cerebral Intracranial Arterial Stenosis segmental narrowing defined by at least two intra-cranial arteries compared with a cohort of non cannabis controls subjects. | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| -Silent ischemic stroke on cerebral MRI | Evaluate on cerebral MRI the presence of sequelae of ischemic stroke defined by a parenchymal hyperintensity in a vascular territory defined on a T2 sequence. | 3 months |
| -new intracranial arterial stenosis at 3 month follow-up |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Valerie Wolff, MD | Contact | 03 88 12 86 06 | 0033 | valerie.wolff@chru-strasbourg.fr |
| Name | Affiliation | Role |
|---|---|---|
| Valerie Wolff, MD | University Hospital, Strasbourg, France | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpitaux Universitaires de Strasbourg | Recruiting | Strasbourg | 67091 | France |
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| ID | Term |
|---|---|
| C502936 | tocilizumab |
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Evaluate a cerebral MRA at 3 months the presence of new intracranial stenosis among cannabis users, according to the prosecution or stopping use |
| 3 months |
| -Reversibility of intracranial arterial stenosis at 3 month follow-up | Evaluate on cerebral MRA at 3 months reversibility stenosis present at T0 in cannabis users having stopped their consumption | 3 months |