PO vs. IV Acetaminophen Given Perioperatively for 24 hr Post-op Pain Control Following Total Hip or Knee Replacement

Randomized, Double-Blind, Study Comparing Oral Acetaminophen Plus Intravenous (IV) Placebo to Oral Placebo Plus IV Acetaminophen Given Perioperatively for Controlling Pain in the 24hr Post-op Period After Total Hip or Knee Joint Replacement

The purpose of the study is to evaluate post-op pain requirements in patients undergoing hip or knee replacement surgery who perioperatively receive either Oral acetaminophen or IV acetaminophen

Subjects will be randomized to receive perioperative dosing of either:

1. Oral acetaminophen (Tylenol) 1000mg with IV Placebo (100ml Normal Saline), OR,
2. IV acetaminophen (Ofirmev) 1000mg/100ml with Oral Placebo (oral capsules).

Subject pain levels and post-operative opioid use will be tracked for up to 24 hours after surgery.

Inclusion Criteria:

• 18 years of age and older
• Able to provide written consent
• Able to read and write in English
• Weighing over 50 kg
• Will undergo total hip or total knee joint replacement

Exclusion Criteria:

• Non-verbal patients
• Unable to use numeric pain scale
• Allergic to the test article
• Documented hepatic impairment or failure
• Current illicit drug use
• Requires traumatic or emergent surgery
• Pregnant women
• Women who are breastfeeding
• Prisoners
• Cognitively impaired requiring Legally Authorized Representative (LAR) or Power of Attorney (POA)
• Unable to swallow oral capsules