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The purpose of study is to investigate if yoga exercise improve life quality and immune status in breast cancer patients after complete treatment (including surgery and / or radiotherapy and / or chemotherapy)
It is well-known that exercise promote immune regulation for better life quality. However, the mechanism for better immunity and life quality is not clear. We postulate that Ayurveda yoga might benefit breast cancer women with completion of operation and/or chemotherapy and radiotherapy. The benefits could be due to immune modulation, and improve health perception and life quality, and even potential decrease of cancer relapse.
The study patients will do yoga twice a week for 12 weeks. The study primary endpoints are 1) to improve personal health perception, 2) to improve life quality and 3) to enhance human immunity. The study secondary endpoint will follow up the immunity changes 3 months after the intervention.
We anticipate to reach the primary endpoints and to publish the primary results in one year, the secondary endpoint will complete in the second year.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Yoga exercise | Experimental | Subjects will receive regular 90-minutes yoga classes twice a week for 3 months. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Yoga exercise | Behavioral | Subjects will receive regular 90-minutes yoga classes twice a week for 3 months. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Improve personal health and life quality | Health and life quality will assessed by modified fatigue inventory and EORTC QLQ-C30 (version 3) at three different times: (1)baseline data: before yoga exercise, (2)outcome data: at 6 and 12 weeks post-test. | Change from baseline in personal health and life quality at 6 months. |
| Measure | Description | Time Frame |
|---|---|---|
| Immune modulation | Lymphocytes will be extracted from peripheral blood for analyses of lymphocytes subpopulation (Th1/ Th2/ Treg/ Th17), polarization (T-bet/ Gata-3/ Foxp3/ RORrt) and its related cytokines (Th1: IL-12/ IFN-γ/ IL-27; Th2: IL-4/ IL-13/ IL-25; Th17: IL-17A/ IL-6/ IL-21; Treg: TGF/ IL-10. Saliva collection for analyses of cortisol and IL-6 at 3 different times: (1) baseline data: before yoga exercise, (2)outcome data: at 6 and 12 weeks post-test. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Shin-Mae Wang, MD. | Contact | wangznmg@gmail.com | ||
| Shu-Hui Yeh Yeh, PhD | Contact | yehshuhui@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Shu-Hui Yeh, PhD | Chang Bing Show Chwan Memorial Hospital & Central Taiwan University of Science and Technology | Study Chair |
| Kuender D. Yang, PhD | Chang Bing Show Chwan Memorial Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Division of Core Laboratory; Chang Bing Show Chwan Memorial Hospital | Recruiting | Changhua County | Taiwan |
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| Change from baseline in human immunity at 3 months. |
| Shin-Mae Wang, MD. | Show Chwan Memorial Hospital | Principal Investigator |