Despite an increasing pharmacopoeia of effective medications for the treatment of bipolar disorder, patient outcomes continue to be impacted by treatment adherence. Non-adherence to treatments is also a major obstacle in translating efficacy in research settings into effectiveness in clinical practice. Non-adherence with bipolar disorder (BD) medication treatment dramatically worsens outcomes. Reasons for non-adherence among individuals with BD are multi-dimensional, and it has been suggested that a multifaceted intervention will be more effective. The study is aimed to assess the effectiveness of a multifaceted intervention on enhancing medications adherence in patients with bipolar disorders.

Inclusion Criteria:

1. age ≥18 years
2. meeting DSM-IV criteria for bipolar I or II disorder
3. concurrently treated with a mood stabilizer
4. not currently in weekly or biweekly psychotherapy
5. Persian speaking.

Exclusion Criteria:

• DSM-IV drug or alcohol misuse disorders (excluding nicotine),
• pregnancy or planning pregnancy in the next year
• requiring changing the drug or the dose of a mood stabilizer
• evidence of severe DSM-IV borderline personality
• Unable or unwilling to give written informed consent.
• An organic cerebral cause for bipolar disorder-for example, multiple sclerosis or stroke.
• intellectual disability