Confocal Laser Endomicroscopy (CLE) could be a useful tool for real-time diagnosis of brain lesions (initial diagnosis or follow-up post resection to check for residual dysplasia) and real-time assessment of resections margins during surgery. Probe-based CLE using the CELLVIZIO® has never been used for glioma surgical guided resection. Before assessing the potential of this technique in improving surgical resection outcome, a feasability study has to be performed.

Inclusion Criteria:

• Patients older than 18 years old
• Clinical signs and history of the disease in favor of a HGG, LGG
• MRI study in favor of a HGG, LGG, meningioma or brain metastasis
• Affiliated to or beneficiary of a social security system (or equivalent).
• Patients who have provided written informed consent for the study

Exclusion Criteria:

• - Allergy to fluorescein
• Previous life-threatening allergic reactions and known hypersensitivity
• Pregnant or lactating or not using effective contraception;
• Restricted renal function define by a creatinine clearance < 30ml/min
• Patients under a beta-blockers treatment
• Contraindication to do an MRI (pace-maker)
• Contraindication to the use of 5-ALA : known hypersensibility to 5-ALA or to porphyrin, acute or chronic porphyria
• Minor or adult ward of court (under guardianship or trusteeship)
• No affiliation to a social security system (or equivalent).
• Patients who express opposition to participation in the study.