Not provided
Not provided
Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| UKSH-HL-14-099 | Other Identifier | Ethicscomittee Luebeck 14-099 |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The following trial is a multicenter and prospective research trial of the colposcopy unit of luebeck university and the national research center in Borstel, Germany.
The study is to identify and evaluate new biomarkers in human papilloma virus (HPV) associated malignancies and its preinvasive lesions of the cervix uteri. Fresh tissue samples being removed during conizations and/or hysterectomies are to be fixed in HOPE's solution and analyzed according to their transcriptomes and methylosome. The hereby found candidates are to be validated using immunohistochemistry and RT [real-time] -PCR [polymerase chain reaction].
The project is meant to be followed by continuous studies developing a new test describing the malignant potential of HPV associated genital lesions.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Measure | Description | Time Frame |
|---|---|---|
| CIN III (cervical intraepithelial neoplasia) lesions | number of CIN III lesions | three years |
| cervical cancer | number of cervical cancer probes | three years |
| HPV | number and type of HPV infection of the analyzed probes | three years |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
The population is to be recruted from A. patients suffering from cervical cancer B. patients suffering from preinvasive cervical lesions
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Daniel Beyer, PD Dr. | University of Luebeck | Principal Investigator |
| Torsten Goldmann, Prof. Dr. | Forschungszentrum Borstel | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Luebeck University, Department for obstetrics and gynecology | Lübeck | Schleswig-Holstein | D-23538 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19621855 | Background | Apgar BS, Kittendorf AL, Bettcher CM, Wong J, Kaufman AJ. Update on ASCCP consensus guidelines for abnormal cervical screening tests and cervical histology. Am Fam Physician. 2009 Jul 15;80(2):147-55. | |
| 19061824 | Background | Gagne HM. Colposcopy of the vagina and vulva. Obstet Gynecol Clin North Am. 2008 Dec;35(4):659-69; x. doi: 10.1016/j.ogc.2008.10.002. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
tissue samples of the cervix uteri
| 19550210 | Background | Massad LS, Jeronimo J, Katki HA, Schiffman M; National Institutes of Health/American Society for Colposcopy and Cervical Pathology Research Group. The accuracy of colposcopic grading for detection of high-grade cervical intraepithelial neoplasia. J Low Genit Tract Dis. 2009 Jul;13(3):137-44. doi: 10.1097/LGT.0b013e31819308d4. |