Combination of Taliderm® and Vacuum-assisted Closure (VAC) for Treatment of Pressure Ulcers

Combination of Taliderm® and VAC for Treatment of Pressure Ulcers - a Pilot Study

Background: The wound healing promoting effect of negative wound pressure therapies (NWPT) takes place at the wound foam interface. Implementation of bioactive substances at this site represents a major research area for the development of future NWPT devices.

Methods: Wound healing kinetics of pressure ulcers treated by vacuum assisted closure devices with or without the implementation of a thin interface of poly-N-acetyl glucosamine nanofibers (sNAG) was studied in a prospective randomized clinical trial.

Inclusion Criteria:

• Ischial/sacral Pressure ulcer between 4 and 15cm diameter
• Greater than or equal to 18 years of age
• Ability to obtain informed consent

Exclusion Criteria:

• Connective tissue disorders
• Immunosuppression, Hemodialysis, Steroids
• Pregnancy
• Sepsis