Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| 140662B-31 | Other Identifier | ANSM (Agence Nationale de Sécurité du Médicament) | |
| 2014-A00649-38 | Other Identifier | ANSM ID RCB |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Fondation pour la Recherche Médicale | OTHER |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Frontal patients are impaired in categorisation and analogical reasoning tasks, and different functional imaging studies from our group have shown the involvement of the prefrontal cortex in categorisation and analogy tasks. The aim of this project is to test our hypotheses about the role of the prefrontal cortex in explicit and implicit categorisation and analogy tasks.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| FTD (frontotemporal dementia) patients | Experimental | fronto-temporal demential patients |
|
| PSP patients | Experimental | progressive supra nuclear palsy patients |
|
| healthy controls | Active Comparator | healthy control education matched, age matched and sex matched with PSP and FTD patients |
|
| healthy participants | Experimental | healthy participants that will participate to the TMS study. |
|
| healthy young participants | Experimental | Healthy participants will be included for an EEG study |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| transcranial magnetic stimulation | Device |
| ||
| MRI imaging |
| Measure | Description | Time Frame |
|---|---|---|
| Performance in the implicat task | Reaction time and accuracy will be registered for this categorization task. This task will be used in patients with FTD and in healthy controls (n=60). Participants will come only once during one day ot the research centre. | day of inclusion (one day) |
| Performance in the Similitude task | Reaction time and accuracy will be recorded while healthy subjects perform this categorization task, after a session of rTMS or during on line TMS (n=40). Participants will come 3 to 5 times at the research centre in a maximum period of 4 months. | from inclusion to 4 months after inclusion |
| Measure | Description | Time Frame |
|---|---|---|
| recording of EEG | EEG will be recorded in patients with FTD and in healthy controls for an analysis of event related potentials. Participants will come only once during one day a the research centre. | day of inclusion (one day) |
| Analysis of MRI |
Not provided
Inclusion Criteria:
Healthy subjects:
Patients:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Richard Levy, MD, PhD | Institut du Cerveau et de la Moelle épinière, Paris | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| ICM (Institut du cerveau et de la Moelle épinière) | Paris | 75013 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34232829 | Result | Ovando-Tellez M, Rohaut B, George N, Bieth T, Hugueville L, Ibrahim Y, Courbet O, Naccache L, Levy R, Garcin B, Volle E. Does adding <i>beer</i> to <i>coffee</i> enhance the activation of <i>drinks</i>? An ERP study of semantic category priming. Cogn Neurosci. 2022 Jan-Jun;13(2):61-76. doi: 10.1080/17588928.2021.1940117. Epub 2021 Jul 7. |
Not provided
Not provided
IPD sharing will be only performed on individual request for a specified study.
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D057180 | Frontotemporal Dementia |
| D013494 | Supranuclear Palsy, Progressive |
| ID | Term |
|---|---|
| D057174 | Frontotemporal Lobar Degeneration |
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D050781 | Transcranial Magnetic Stimulation |
| D009483 | Neuropsychological Tests |
| ID | Term |
|---|---|
| D055909 | Magnetic Field Therapy |
| D013812 | Therapeutics |
| D011581 | Psychological Tests |
| D004191 | Behavioral Disciplines and Activities |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Other |
|
| EEG recording | Other |
|
| Neuropsychological examination | Behavioral |
|
T1 MRI will be recorded for VBM analysis in patients with FTD and healthy controls.
Participants will come only once during one day at the research centre
| day of inclusion (one day) |
| D009422 | Nervous System Diseases |
| D057177 | TDP-43 Proteinopathies |
| D019636 | Neurodegenerative Diseases |
| D057165 | Proteostasis Deficiencies |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D001480 | Basal Ganglia Diseases |
| D009069 | Movement Disorders |
| D009886 | Ophthalmoplegia |
| D015835 | Ocular Motility Disorders |
| D003389 | Cranial Nerve Diseases |
| D024801 | Tauopathies |
| D010243 | Paralysis |
| D009461 | Neurologic Manifestations |
| D005128 | Eye Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |