The primary objective of the study is to evaluate the efficacy in wrinkle reduction of a single treatment of three different doses of botulinum toxin compared to placebo, in the treatment of moderate to very severe glabellar frown lines.

Inclusion Criteria:

• Moderate to Very Severe glabellar lines at maximum frown as assessed by the subject and the Investigator and at least Mild glabellar lines at rest

Exclusion Criteria:

• Any previous treatment with any botulinum toxin
• Rhytids of the glabellar region that cannot be smoothed out by manually spreading the skin apart
• Any previous insertion of any permanent or semi-permanent material, hyaluronic acid or collagen fillers to the glabellar region
• Any history of facial surgery above the lower orbital rim
• Any planned facial surgery or aesthetic procedure during the study period
• Ablative skin resurfacing or chemical peels above the lower orbital rim in the previous 12 months or during the study period