Diagnostic Yield of Transbronchial Cryobiopsy in Diagnosis of Interstitial Lung Diseases

DIagnostic Yield of Transbronchial Cryobiopsies in Subjects With Interstitial Lung Disease

Evaluation of diagnostic yield, feasibility and safety of transbronchial lung cryobiopsies done via bronchoscopy in the investigation of interstitial lung disease in comparison with videothoracoscopy-assisted surgical lung biopsy.

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Inclusion Criteria:

• Volunteer subjects with interstitial lung disease in whom a surgical lung biopsy is planned for diagnostic investigation.

Exclusion Criteria:

• Aged less than 18 y.o.
• Pregnancy
• Known coagulatoin disorder or blood dyscrasia
• Aaking antiplatelet agents other than aspirin or therapeutic anticoagulants drugs that cannot be safely discontinued to undergo lung biopsy
• Arterial oxgen pressure less than 60 mmHg on more than 2 liters per minute oxygen
• Known pulmonary hypertension defined as systolic PAP above 40 mmHg on echocardiography
• Unable to provide informed consent