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Evaluation of diagnostic yield, feasibility and safety of transbronchial lung cryobiopsies done via bronchoscopy in the investigation of interstitial lung disease in comparison with videothoracoscopy-assisted surgical lung biopsy.
See above
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cryobiopsy | Other |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transbronchial lung cryobiopsy | Other |
|
| Measure | Description | Time Frame |
|---|---|---|
| Overall diagnostic yield of cryobiopsy specimens in interstitial lung disease | Number of cryobiopsy specimens from which a specific diagnosis of interstitial lung disease can be ascertained, as assessed by a two different pathologists blinded to the known final diagnosis. | After biopsy (up to 24 months) |
| Measure | Description | Time Frame |
|---|---|---|
| Complication rate of transbronchial cryobiopsy procedure | Assessment of complications related to cryoTBB:
| Per-procedure and up to 24 hours after |
| Number of diagnostic specimens of cryoTBB in comparison with surgical lung biopsy specimen |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Antoine Delage, MDCM | Contact | 418-656-4747 | antoine.delage@criucpq.ulaval.ca |
| Name | Affiliation | Role |
|---|---|---|
| Antoine Delage, MDCM | Institut universitaire de cardiologie et de pneumologie de Québec, University Laval | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Institut universitaire de cardiologie et de pneumologie de Québec | Recruiting | Québec | G1V 4G5 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36796092 | Derived | Fortin M, Liberman M, Delage A, Dion G, Martel S, Rolland F, Soumagne T, Trahan S, Assayag D, Albert E, Kelly MM, Johannson KA, Guenther Z, Leduc C, Manganas H, Prenovault J, Provencher S. Transbronchial Lung Cryobiopsy and Surgical Lung Biopsy: A Prospective Multi-Centre Agreement Clinical Trial (CAN-ICE). Am J Respir Crit Care Med. 2023 Jun 15;207(12):1612-1619. doi: 10.1164/rccm.202209-1812OC. |
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| ID | Term |
|---|---|
| D017563 | Lung Diseases, Interstitial |
| D011658 | Pulmonary Fibrosis |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D005355 | Fibrosis |
| D010335 | Pathologic Processes |
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Diagnostic concordance between cryobiopsy specimen analysis and corresponding surgical lung biopsy done in same subjects (same lung/lobe) |
| After biopsy (up to 24 months) |
| Inter-observer agreement for cryobiopsy specimens | Interobserver agreement rate between two different pathologists blinded to subject history/radiological record and surgical lung biopsy specimen. | After biopsy (up to 24 months) |
| Size of cryobiopsy specimen | Size of TBB cryobiopsy specimen measured by two different pathologists responsible for its interpretation. | After biopsy (up to 24months) |
| Quality of cyrobiopsy specimens | Pathological quality score of TBB cryobiopsy specimens (artefacts, size, etc.) as assessed by two different pathologists responsible for their interpretation. | After biopsy (up to 24 months) |
| D013568 |
| Pathological Conditions, Signs and Symptoms |