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| Name | Class |
|---|---|
| National Institute on Drug Abuse (NIDA) | NIH |
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This study will determine the safety and tolerability of phendimetrazine (Bontril®) as a pharmacotherapy for cocaine use disorder. A rigorous, inpatient human laboratory study will be conducted in which the subjective and physiological effects of cocaine are evaluated during maintenance on placebo and phendimetrazine.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | Subjects will be maintained on oral placebo. Cocaine will be administered acutely during placebo maintenance. Placebo will be administered acutely during placebo maintenance. |
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| Phendimetrazine Dose 1 | Experimental | Subjects will be maintained on the low phendimetrazine dose. Cocaine will be administered acutely during low dose phendimetrazine maintenance. Placebo will be administered acutely during low dose phendimetrazine maintenance. |
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| Phendimetrazine Dose 2 | Experimental | Subjects will be maintained on the intermediate phendimetrazine dose. Cocaine will be administered acutely during intermediate dose phendimetrazine maintenance. Placebo will be administered acutely during intermediate dose phendimetrazine maintenance. |
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| Phendimetrazine Dose 3 | Experimental | Subjects will be maintained on the high phendimetrazine dose. Cocaine will be administered acutely during high dose phendimetrazine maintenance. Placebo will be administered acutely during high dose phendimetrazine maintenance. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cocaine | Drug | The pharmacodynamic effects of cocaine will be determined during maintenance on placebo and phendimetrazine. |
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| Measure | Description | Time Frame |
|---|---|---|
| Peak Systolic Pressure | Systolic blood pressure was measured with an automated monitor. Higher values represent greater systolic pressure. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo maintenance conditions. | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
| Peak Diastolic Pressure | Diastolic blood pressure was measured with an automated monitor. Higher values represent greater diastolic pressure. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo maintenance conditions. | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
| Peak Heart Rate | Heart rate was measured with an automated monitor. Higher values represent greater heart rate. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo maintenance conditions. | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
| Peak Temperature | Oral temperature was measured with an automated monitor. Higher values represent greater temperature. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo maintenance conditions. | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
| Measure | Description | Time Frame |
|---|---|---|
| Peak Score on Sedative Subscale of the Adjective Rating Scale | Subjects completed 16 items that loaded into the Sedative Subscale of the Adjective Rating Scale. The items were rated 0-4 on a Likert-type scale and the sum for the 16 "sedative" items was summed to yield the Sedative Subscale score. The maximum score for this scale was 64, the minimum was 0. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| William W Stoops, Ph.D. | University of Kentucky | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Kentucky Laboratory of Human Behavioral Pharmacology | Lexington | Kentucky | 40507 | United States |
Eleven subjects were enrolled (i.e., signed consent), but only 10 subjects completed. Due to the within-subject nature of this study (i.e., missing data from the 11th subject cannot be analyzed with repeated-measures ANOVA), only data from the 10 subjects who completed the protocol were analyzed and reported.
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| ID | Title | Description |
|---|---|---|
| FG000 | Phendimetrazine Dose Escalation | Subjects were maintained on oral placebo, 70 mg phendimetrazine/day, 140 mg phendimetrazine/day and 210 mg phendimetrazine/day in ascending order. Intranasal cocaine (10, 20, 40 and 80 mg) was administered acutely after at least seven days of maintenance on each condition. Intransasal placebo cocaine was administered acutely after at least seven days of maintenance on each condition. Cocaine: The pharmacodynamic effects of cocaine were determined during maintenance on placebo and phendimetrazine. Placebo: The pharmacodynamic effects of placebo were determined during maintenance on placebo and phendimetrazine. |
| Title | Milestones | Reasons Not Completed | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
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These are data for completing subjects only. Eleven subjects were enrolled (i.e., signed consent), but only data from completing subjects were included here and in the outcomes listed throughout this report.
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| ID | Title | Description |
|---|---|---|
| BG000 | Phendimetrazine Dose Escalation | Subjects were maintained on oral placebo, 70 mg phendimetrazine/day, 140 mg phendimetrazine/day and 210 mg phendimetrazine/day in ascending order. Cocaine was administered acutely after at least seven days of maintenance on each condition. Placebo cocaine was administered acutely after at least seven days of maintenance on each condition. Cocaine: The pharmacodynamic effects of cocaine were determined during maintenance on placebo and phendimetrazine. Placebo: The pharmacodynamic effects of placebo cocaine were determined during maintenance on placebo and phendimetrazine. |
| Units | Counts |
|---|---|
| Participants |
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| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Peak Systolic Pressure | Systolic blood pressure was measured with an automated monitor. Higher values represent greater systolic pressure. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo maintenance conditions. | Posted | Mean | Standard Error | mm Hg | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Phendimetrazine Dose Escalation | Subjects were maintained on oral placebo, 70 mg phendimetrazine/day, 140 mg phendimetrazine/day and 210 mg phendimetrazine/day in ascending order. Intranasal cocaine (10, 20, 40 and 80 mg) was administered acutely after at least seven days of maintenance on each condition. Intransasal placebo cocaine was administered acutely after at least seven days of maintenance on each condition. Cocaine: The pharmacodynamic effects of cocaine were determined during maintenance on placebo and phendimetrazine. Placebo: The pharmacodynamic effects of placebo were determined during maintenance on placebo and phendimetrazine. |
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| Term | Organ System | Source Vocabulary | Assessment Type | Notes | Statistical Information |
|---|---|---|---|---|---|
| Persistent Tachycardia | Cardiac disorders | Systematic Assessment | One subject experienced persistent tachycardia after receiving 10 mg cocaine during placebo maintenance and was discharged from the protocol after the event resolved. |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| William W. Stoops, Ph.D. | University of Kentucky | 859-257-5388 | william.stoops@uky.edu |
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| ID | Term |
|---|---|
| D003042 | Cocaine |
| ID | Term |
|---|---|
| D014326 | Tropanes |
| D053961 | Azabicyclo Compounds |
| D001372 | Aza Compounds |
| D009930 | Organic Chemicals |
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| Placebo | Drug | The pharmacodynamic effects of placebo will be determined during maintenance on placebo and phendimetrazine. |
|
| This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
| Peak Score on Stimulant Subscale of the Adjective Rating Scale | Subjects completed 16 items that loaded into the Stimulant Subscale of the Adjective Rating Scale. The items were rated 0-4 on a Likert-type scale and the sum for the 16 "stimulant" items was summed to yield the Stimulant Subscale score. The maximum score for this scale was 64, the minimum was 0. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
| Peak Ratings of "Active, Alert, Energetic" on the Visual Analog Scale | Subjects rated their feelings of "Active, Alert, Energetic" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
| Peak Ratings of "Any Effect" on the Visual Analog Scale | Subjects rated their feelings of "Any Effect" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
| Peak Ratings of "Bad Effect" on the Visual Analog Scale | Subjects rated their feelings of "Bad Effect" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
| Peak Ratings of "Euphoric" on the Visual Analog Scale | Subjects rated their feelings of "Euphoric" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
| Peak Ratings of "Good Effect" on the Visual Analog Scale | Subjects rated their feelings of "Good Effect" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
| Peak Ratings of "High" on the Visual Analog Scale | Subjects rated their feelings of "High" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
| Peak Ratings of "Irregular/Racing Heartbeat" on the Visual Analog Scale | Subjects rated their feelings of "Irregular/Racing Heartbeat" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
| Peak Ratings of "Like Drug" on the Visual Analog Scale | Subjects rated their feelings of "Like Drug" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
| Peak Ratings of "Nauseated/Queasy/Sick to Stomach" on the Visual Analog Scale | Subjects rated their feelings of "Nauseated/Queasy/Sick to Stomach" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
| Peak Ratings of "Nervous/Anxious" on the Visual Analog Scale | Subjects rated their feelings of "Nervous/Anxious" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
| Peak Ratings of "Willing to Pay For" on the Visual Analog Scale | Subjects rated their feelings of "Willing to Pay For" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
| Peak Ratings of "Performance Impaired" on the Visual Analog Scale | Subjects rated their feelings of "Performance Impaired" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
| Peak Ratings of "Performance Improved" on the Visual Analog Scale | Subjects rated their feelings of "Performance Improved" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
| Peak Ratings of "Restless" on the Visual Analog Scale | Subjects rated their feelings of "Restless" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
| Peak Ratings of "Rush" on the Visual Analog Scale | Subjects rated their feelings of "Rush" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
| Peak Ratings of "Shaky/Jittery" on the Visual Analog Scale | Subjects rated their feelings of "Shaky/Jittery" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
| Peak Ratings of "Sluggish/Fatigued/Lazy" on the Visual Analog Scale | Subjects rated their feelings of "Sluggish/Fatigued/Lazy" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
| Peak Ratings of "Stimulated" on the Visual Analog Scale | Subjects rated their feelings of "Stimulated" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
| Peak Ratings of "Willing to Take Again" on the Visual Analog Scale | Subjects rated their feelings of "Willing to Take Again" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
| Peak Ratings of "Talkative/Friendly" on the Visual Analog Scale | Subjects rated their feelings of "Talkative/Friendly" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
| years |
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| Sex: Female, Male | Count of Participants | Participants |
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| Ethnicity (NIH/OMB) | Count of Participants | Participants |
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| Race (NIH/OMB) | Count of Participants | Participants |
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| Region of Enrollment | Number | participants |
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| Primary | Peak Diastolic Pressure | Diastolic blood pressure was measured with an automated monitor. Higher values represent greater diastolic pressure. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo maintenance conditions. | Posted | Mean | Standard Error | mm Hg | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
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| Primary | Peak Heart Rate | Heart rate was measured with an automated monitor. Higher values represent greater heart rate. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo maintenance conditions. | Posted | Mean | Standard Error | Beats per Minute | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
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| Primary | Peak Temperature | Oral temperature was measured with an automated monitor. Higher values represent greater temperature. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo maintenance conditions. | Posted | Mean | Standard Error | Degrees Fahrenheit | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
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| Secondary | Peak Score on Sedative Subscale of the Adjective Rating Scale | Subjects completed 16 items that loaded into the Sedative Subscale of the Adjective Rating Scale. The items were rated 0-4 on a Likert-type scale and the sum for the 16 "sedative" items was summed to yield the Sedative Subscale score. The maximum score for this scale was 64, the minimum was 0. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | Posted | Mean | Standard Error | units on a scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
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| Secondary | Peak Score on Stimulant Subscale of the Adjective Rating Scale | Subjects completed 16 items that loaded into the Stimulant Subscale of the Adjective Rating Scale. The items were rated 0-4 on a Likert-type scale and the sum for the 16 "stimulant" items was summed to yield the Stimulant Subscale score. The maximum score for this scale was 64, the minimum was 0. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | Posted | Mean | Standard Error | units on a scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
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| Secondary | Peak Ratings of "Active, Alert, Energetic" on the Visual Analog Scale | Subjects rated their feelings of "Active, Alert, Energetic" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | Posted | Mean | Standard Error | units on a scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
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| Secondary | Peak Ratings of "Any Effect" on the Visual Analog Scale | Subjects rated their feelings of "Any Effect" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | Posted | Mean | Standard Error | units on a scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
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| Secondary | Peak Ratings of "Bad Effect" on the Visual Analog Scale | Subjects rated their feelings of "Bad Effect" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | Posted | Mean | Standard Error | units on a scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
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| Secondary | Peak Ratings of "Euphoric" on the Visual Analog Scale | Subjects rated their feelings of "Euphoric" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | Posted | Mean | Standard Error | units on a scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
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| Secondary | Peak Ratings of "Good Effect" on the Visual Analog Scale | Subjects rated their feelings of "Good Effect" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | Posted | Mean | Standard Error | units on a scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
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| Secondary | Peak Ratings of "High" on the Visual Analog Scale | Subjects rated their feelings of "High" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | Posted | Mean | Standard Error | units on a scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
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| Secondary | Peak Ratings of "Irregular/Racing Heartbeat" on the Visual Analog Scale | Subjects rated their feelings of "Irregular/Racing Heartbeat" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | Posted | Mean | Standard Error | units on a scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
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| Secondary | Peak Ratings of "Like Drug" on the Visual Analog Scale | Subjects rated their feelings of "Like Drug" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | Posted | Mean | Standard Error | units on a scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
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| Secondary | Peak Ratings of "Nauseated/Queasy/Sick to Stomach" on the Visual Analog Scale | Subjects rated their feelings of "Nauseated/Queasy/Sick to Stomach" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | Posted | Mean | Standard Error | units on a scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
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| Secondary | Peak Ratings of "Nervous/Anxious" on the Visual Analog Scale | Subjects rated their feelings of "Nervous/Anxious" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | Posted | Mean | Standard Error | units on a scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
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| Secondary | Peak Ratings of "Willing to Pay For" on the Visual Analog Scale | Subjects rated their feelings of "Willing to Pay For" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | Posted | Mean | Standard Error | units on a scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
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| Secondary | Peak Ratings of "Performance Impaired" on the Visual Analog Scale | Subjects rated their feelings of "Performance Impaired" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | Posted | Mean | Standard Error | units on a scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
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| Secondary | Peak Ratings of "Performance Improved" on the Visual Analog Scale | Subjects rated their feelings of "Performance Improved" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | Posted | Mean | Standard Error | units on a scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
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| Secondary | Peak Ratings of "Restless" on the Visual Analog Scale | Subjects rated their feelings of "Restless" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | Posted | Mean | Standard Error | units on a scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
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| Secondary | Peak Ratings of "Rush" on the Visual Analog Scale | Subjects rated their feelings of "Rush" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | Posted | Mean | Standard Error | units on a scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
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| Secondary | Peak Ratings of "Shaky/Jittery" on the Visual Analog Scale | Subjects rated their feelings of "Shaky/Jittery" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | Posted | Mean | Standard Error | units on a scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
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| Secondary | Peak Ratings of "Sluggish/Fatigued/Lazy" on the Visual Analog Scale | Subjects rated their feelings of "Sluggish/Fatigued/Lazy" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | Posted | Mean | Standard Error | units on a scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
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| Secondary | Peak Ratings of "Stimulated" on the Visual Analog Scale | Subjects rated their feelings of "Stimulated" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | Posted | Mean | Standard Error | units on a scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
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|
|
| Secondary | Peak Ratings of "Willing to Take Again" on the Visual Analog Scale | Subjects rated their feelings of "Willing to Take Again" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | Posted | Mean | Standard Error | units on a scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
|
|
|
| Secondary | Peak Ratings of "Talkative/Friendly" on the Visual Analog Scale | Subjects rated their feelings of "Talkative/Friendly" on a Visual Analog Scale. This item was rated from 0 (minimum)-100 (maximum) on a Visual Analog Scale. Higher values represent greater subjective effects on this item. Peak scores were calculated from multiple assessments for each cocaine dose under both phendimetrazine and placebo conditions. | Posted | Mean | Standard Error | units on a scale | This measure was completed at 15 minute intervals after sampling each cocaine dose under both phendimetrazine and placebo maintenance conditions. |
|
|
|
| 0 |
| 11 |
| 1 |
| 11 |
|
Not provided
Not provided
| D000470 |
| Alkaloids |
| D006571 | Heterocyclic Compounds |
| D019086 | Bridged Bicyclo Compounds, Heterocyclic |
| D006572 | Heterocyclic Compounds, Bridged-Ring |
|
| 40 mg Cocaine with 0 mg Phendimetrazine |
|
| 80 mg Cocaine with 0 mg Phendimetrazine |
|
| 0 mg Cocaine with 70 mg Phendimetrazine |
|
| 10 mg Cocaine with 70 mg Phendimetrazine |
|
| 20 mg Cocaine with 70 mg Phendimetrazine |
|
| 40 mg Cocaine with 70 mg Phendimetrazine |
|
| 80 mg Cocaine with 70 mg Phendimetrazine |
|
| 0 mg Cocaine with 140 mg Phendimetrazine |
|
| 10 mg Cocaine with 140 mg Phendimetrazine |
|
| 20 mg Cocaine with 140 mg Phendimetrazine |
|
| 40 mg Cocaine with 140 mg Phendimetrazine |
|
| 80 mg Cocaine with 140 mg Phendimetrazine |
|
| 0 mg Cocaine with 210 mg Phendimetrazine |
|
| 10 mg Cocaine with 210 mg Phendimetrazine |
|
| 20 mg Cocaine with 210 mg Phendimetrazine |
|
| 40 mg Cocaine with 210 mg Phendimetrazine |
|
| 80 mg Cocaine with 210 mg Phendimetrazine |
|
|
| 40 mg Cocaine with 0 mg Phendimetrazine |
|
| 80 mg Cocaine with 0 mg Phendimetrazine |
|
| 0 mg Cocaine with 70 mg Phendimetrazine |
|
| 10 mg Cocaine with 70 mg Phendimetrazine |
|
| 20 mg Cocaine with 70 mg Phendimetrazine |
|
| 40 mg Cocaine with 70 mg Phendimetrazine |
|
| 80 mg Cocaine with 70 mg Phendimetrazine |
|
| 0 mg Cocaine with 140 mg Phendimetrazine |
|
| 10 mg Cocaine with 140 mg Phendimetrazine |
|
| 20 mg Cocaine with 140 mg Phendimetrazine |
|
| 40 mg Cocaine with 140 mg Phendimetrazine |
|
| 80 mg Cocaine with 140 mg Phendimetrazine |
|
| 0 mg Cocaine with 210 mg Phendimetrazine |
|
| 10 mg Cocaine with 210 mg Phendimetrazine |
|
| 20 mg Cocaine with 210 mg Phendimetrazine |
|
| 40 mg Cocaine with 210 mg Phendimetrazine |
|
| 80 mg Cocaine with 210 mg Phendimetrazine |
|
|
| 40 mg Cocaine with 0 mg Phendimetrazine |
|
| 80 mg Cocaine with 0 mg Phendimetrazine |
|
| 0 mg Cocaine with 70 mg Phendimetrazine |
|
| 10 mg Cocaine with 70 mg Phendimetrazine |
|
| 20 mg Cocaine with 70 mg Phendimetrazine |
|
| 40 mg Cocaine with 70 mg Phendimetrazine |
|
| 80 mg Cocaine with 70 mg Phendimetrazine |
|
| 0 mg Cocaine with 140 mg Phendimetrazine |
|
| 10 mg Cocaine with 140 mg Phendimetrazine |
|
| 20 mg Cocaine with 140 mg Phendimetrazine |
|
| 40 mg Cocaine with 140 mg Phendimetrazine |
|
| 80 mg Cocaine with 140 mg Phendimetrazine |
|
| 0 mg Cocaine with 210 mg Phendimetrazine |
|
| 10 mg Cocaine with 210 mg Phendimetrazine |
|
| 20 mg Cocaine with 210 mg Phendimetrazine |
|
| 40 mg Cocaine with 210 mg Phendimetrazine |
|
| 80 mg Cocaine with 210 mg Phendimetrazine |
|
|
| 40 mg Cocaine with 0 mg Phendimetrazine |
|
| 80 mg Cocaine with 0 mg Phendimetrazine |
|
| 0 mg Cocaine with 70 mg Phendimetrazine |
|
| 10 mg Cocaine with 70 mg Phendimetrazine |
|
| 20 mg Cocaine with 70 mg Phendimetrazine |
|
| 40 mg Cocaine with 70 mg Phendimetrazine |
|
| 80 mg Cocaine with 70 mg Phendimetrazine |
|
| 0 mg Cocaine with 140 mg Phendimetrazine |
|
| 10 mg Cocaine with 140 mg Phendimetrazine |
|
| 20 mg Cocaine with 140 mg Phendimetrazine |
|
| 40 mg Cocaine with 140 mg Phendimetrazine |
|
| 80 mg Cocaine with 140 mg Phendimetrazine |
|
| 0 mg Cocaine with 210 mg Phendimetrazine |
|
| 10 mg Cocaine with 210 mg Phendimetrazine |
|
| 20 mg Cocaine with 210 mg Phendimetrazine |
|
| 40 mg Cocaine with 210 mg Phendimetrazine |
|
| 80 mg Cocaine with 210 mg Phendimetrazine |
|
|
| 40 mg Cocaine with 0 mg Phendimetrazine |
|
| 80 mg Cocaine with 0 mg Phendimetrazine |
|
| 0 mg Cocaine with 70 mg Phendimetrazine |
|
| 10 mg Cocaine with 70 mg Phendimetrazine |
|
| 20 mg Cocaine with 70 mg Phendimetrazine |
|
| 40 mg Cocaine with 70 mg Phendimetrazine |
|
| 80 mg Cocaine with 70 mg Phendimetrazine |
|
| 0 mg Cocaine with 140 mg Phendimetrazine |
|
| 10 mg Cocaine with 140 mg Phendimetrazine |
|
| 20 mg Cocaine with 140 mg Phendimetrazine |
|
| 40 mg Cocaine with 140 mg Phendimetrazine |
|
| 80 mg Cocaine with 140 mg Phendimetrazine |
|
| 0 mg Cocaine with 210 mg Phendimetrazine |
|
| 10 mg Cocaine with 210 mg Phendimetrazine |
|
| 20 mg Cocaine with 210 mg Phendimetrazine |
|
| 40 mg Cocaine with 210 mg Phendimetrazine |
|
| 80 mg Cocaine with 210 mg Phendimetrazine |
|
|
| 40 mg Cocaine with 0 mg Phendimetrazine |
|
| 80 mg Cocaine with 0 mg Phendimetrazine |
|
| 0 mg Cocaine with 70 mg Phendimetrazine |
|
| 10 mg Cocaine with 70 mg Phendimetrazine |
|
| 20 mg Cocaine with 70 mg Phendimetrazine |
|
| 40 mg Cocaine with 70 mg Phendimetrazine |
|
| 80 mg Cocaine with 70 mg Phendimetrazine |
|
| 0 mg Cocaine with 140 mg Phendimetrazine |
|
| 10 mg Cocaine with 140 mg Phendimetrazine |
|
| 20 mg Cocaine with 140 mg Phendimetrazine |
|
| 40 mg Cocaine with 140 mg Phendimetrazine |
|
| 80 mg Cocaine with 140 mg Phendimetrazine |
|
| 0 mg Cocaine with 210 mg Phendimetrazine |
|
| 10 mg Cocaine with 210 mg Phendimetrazine |
|
| 20 mg Cocaine with 210 mg Phendimetrazine |
|
| 40 mg Cocaine with 210 mg Phendimetrazine |
|
| 80 mg Cocaine with 210 mg Phendimetrazine |
|
|
| 40 mg Cocaine with 0 mg Phendimetrazine |
|
| 80 mg Cocaine with 0 mg Phendimetrazine |
|
| 0 mg Cocaine with 70 mg Phendimetrazine |
|
| 10 mg Cocaine with 70 mg Phendimetrazine |
|
| 20 mg Cocaine with 70 mg Phendimetrazine |
|
| 40 mg Cocaine with 70 mg Phendimetrazine |
|
| 80 mg Cocaine with 70 mg Phendimetrazine |
|
| 0 mg Cocaine with 140 mg Phendimetrazine |
|
| 10 mg Cocaine with 140 mg Phendimetrazine |
|
| 20 mg Cocaine with 140 mg Phendimetrazine |
|
| 40 mg Cocaine with 140 mg Phendimetrazine |
|
| 80 mg Cocaine with 140 mg Phendimetrazine |
|
| 0 mg Cocaine with 210 mg Phendimetrazine |
|
| 10 mg Cocaine with 210 mg Phendimetrazine |
|
| 20 mg Cocaine with 210 mg Phendimetrazine |
|
| 40 mg Cocaine with 210 mg Phendimetrazine |
|
| 80 mg Cocaine with 210 mg Phendimetrazine |
|
|
| 40 mg Cocaine with 0 mg Phendimetrazine |
|
| 80 mg Cocaine with 0 mg Phendimetrazine |
|
| 0 mg Cocaine with 70 mg Phendimetrazine |
|
| 10 mg Cocaine with 70 mg Phendimetrazine |
|
| 20 mg Cocaine with 70 mg Phendimetrazine |
|
| 40 mg Cocaine with 70 mg Phendimetrazine |
|
| 80 mg Cocaine with 70 mg Phendimetrazine |
|
| 0 mg Cocaine with 140 mg Phendimetrazine |
|
| 10 mg Cocaine with 140 mg Phendimetrazine |
|
| 20 mg Cocaine with 140 mg Phendimetrazine |
|
| 40 mg Cocaine with 140 mg Phendimetrazine |
|
| 80 mg Cocaine with 140 mg Phendimetrazine |
|
| 0 mg Cocaine with 210 mg Phendimetrazine |
|
| 10 mg Cocaine with 210 mg Phendimetrazine |
|
| 20 mg Cocaine with 210 mg Phendimetrazine |
|
| 40 mg Cocaine with 210 mg Phendimetrazine |
|
| 80 mg Cocaine with 210 mg Phendimetrazine |
|
|
| 40 mg Cocaine with 0 mg Phendimetrazine |
|
| 80 mg Cocaine with 0 mg Phendimetrazine |
|
| 0 mg Cocaine with 70 mg Phendimetrazine |
|
| 10 mg Cocaine with 70 mg Phendimetrazine |
|
| 20 mg Cocaine with 70 mg Phendimetrazine |
|
| 40 mg Cocaine with 70 mg Phendimetrazine |
|
| 80 mg Cocaine with 70 mg Phendimetrazine |
|
| 0 mg Cocaine with 140 mg Phendimetrazine |
|
| 10 mg Cocaine with 140 mg Phendimetrazine |
|
| 20 mg Cocaine with 140 mg Phendimetrazine |
|
| 40 mg Cocaine with 140 mg Phendimetrazine |
|
| 80 mg Cocaine with 140 mg Phendimetrazine |
|
| 0 mg Cocaine with 210 mg Phendimetrazine |
|
| 10 mg Cocaine with 210 mg Phendimetrazine |
|
| 20 mg Cocaine with 210 mg Phendimetrazine |
|
| 40 mg Cocaine with 210 mg Phendimetrazine |
|
| 80 mg Cocaine with 210 mg Phendimetrazine |
|
|
| 40 mg Cocaine with 0 mg Phendimetrazine |
|
| 80 mg Cocaine with 0 mg Phendimetrazine |
|
| 0 mg Cocaine with 70 mg Phendimetrazine |
|
| 10 mg Cocaine with 70 mg Phendimetrazine |
|
| 20 mg Cocaine with 70 mg Phendimetrazine |
|
| 40 mg Cocaine with 70 mg Phendimetrazine |
|
| 80 mg Cocaine with 70 mg Phendimetrazine |
|
| 0 mg Cocaine with 140 mg Phendimetrazine |
|
| 10 mg Cocaine with 140 mg Phendimetrazine |
|
| 20 mg Cocaine with 140 mg Phendimetrazine |
|
| 40 mg Cocaine with 140 mg Phendimetrazine |
|
| 80 mg Cocaine with 140 mg Phendimetrazine |
|
| 0 mg Cocaine with 210 mg Phendimetrazine |
|
| 10 mg Cocaine with 210 mg Phendimetrazine |
|
| 20 mg Cocaine with 210 mg Phendimetrazine |
|
| 40 mg Cocaine with 210 mg Phendimetrazine |
|
| 80 mg Cocaine with 210 mg Phendimetrazine |
|
|
| 40 mg Cocaine with 0 mg Phendimetrazine |
|
| 80 mg Cocaine with 0 mg Phendimetrazine |
|
| 0 mg Cocaine with 70 mg Phendimetrazine |
|
| 10 mg Cocaine with 70 mg Phendimetrazine |
|
| 20 mg Cocaine with 70 mg Phendimetrazine |
|
| 40 mg Cocaine with 70 mg Phendimetrazine |
|
| 80 mg Cocaine with 70 mg Phendimetrazine |
|
| 0 mg Cocaine with 140 mg Phendimetrazine |
|
| 10 mg Cocaine with 140 mg Phendimetrazine |
|
| 20 mg Cocaine with 140 mg Phendimetrazine |
|
| 40 mg Cocaine with 140 mg Phendimetrazine |
|
| 80 mg Cocaine with 140 mg Phendimetrazine |
|
| 0 mg Cocaine with 210 mg Phendimetrazine |
|
| 10 mg Cocaine with 210 mg Phendimetrazine |
|
| 20 mg Cocaine with 210 mg Phendimetrazine |
|
| 40 mg Cocaine with 210 mg Phendimetrazine |
|
| 80 mg Cocaine with 210 mg Phendimetrazine |
|
|
| 40 mg Cocaine with 0 mg Phendimetrazine |
|
| 80 mg Cocaine with 0 mg Phendimetrazine |
|
| 0 mg Cocaine with 70 mg Phendimetrazine |
|
| 10 mg Cocaine with 70 mg Phendimetrazine |
|
| 20 mg Cocaine with 70 mg Phendimetrazine |
|
| 40 mg Cocaine with 70 mg Phendimetrazine |
|
| 80 mg Cocaine with 70 mg Phendimetrazine |
|
| 0 mg Cocaine with 140 mg Phendimetrazine |
|
| 10 mg Cocaine with 140 mg Phendimetrazine |
|
| 20 mg Cocaine with 140 mg Phendimetrazine |
|
| 40 mg Cocaine with 140 mg Phendimetrazine |
|
| 80 mg Cocaine with 140 mg Phendimetrazine |
|
| 0 mg Cocaine with 210 mg Phendimetrazine |
|
| 10 mg Cocaine with 210 mg Phendimetrazine |
|
| 20 mg Cocaine with 210 mg Phendimetrazine |
|
| 40 mg Cocaine with 210 mg Phendimetrazine |
|
| 80 mg Cocaine with 210 mg Phendimetrazine |
|
|
| 40 mg Cocaine with 0 mg Phendimetrazine |
|
| 80 mg Cocaine with 0 mg Phendimetrazine |
|
| 0 mg Cocaine with 70 mg Phendimetrazine |
|
| 10 mg Cocaine with 70 mg Phendimetrazine |
|
| 20 mg Cocaine with 70 mg Phendimetrazine |
|
| 40 mg Cocaine with 70 mg Phendimetrazine |
|
| 80 mg Cocaine with 70 mg Phendimetrazine |
|
| 0 mg Cocaine with 140 mg Phendimetrazine |
|
| 10 mg Cocaine with 140 mg Phendimetrazine |
|
| 20 mg Cocaine with 140 mg Phendimetrazine |
|
| 40 mg Cocaine with 140 mg Phendimetrazine |
|
| 80 mg Cocaine with 140 mg Phendimetrazine |
|
| 0 mg Cocaine with 210 mg Phendimetrazine |
|
| 10 mg Cocaine with 210 mg Phendimetrazine |
|
| 20 mg Cocaine with 210 mg Phendimetrazine |
|
| 40 mg Cocaine with 210 mg Phendimetrazine |
|
| 80 mg Cocaine with 210 mg Phendimetrazine |
|
|
| 40 mg Cocaine with 0 mg Phendimetrazine |
|
| 80 mg Cocaine with 0 mg Phendimetrazine |
|
| 0 mg Cocaine with 70 mg Phendimetrazine |
|
| 10 mg Cocaine with 70 mg Phendimetrazine |
|
| 20 mg Cocaine with 70 mg Phendimetrazine |
|
| 40 mg Cocaine with 70 mg Phendimetrazine |
|
| 80 mg Cocaine with 70 mg Phendimetrazine |
|
| 0 mg Cocaine with 140 mg Phendimetrazine |
|
| 10 mg Cocaine with 140 mg Phendimetrazine |
|
| 20 mg Cocaine with 140 mg Phendimetrazine |
|
| 40 mg Cocaine with 140 mg Phendimetrazine |
|
| 80 mg Cocaine with 140 mg Phendimetrazine |
|
| 0 mg Cocaine with 210 mg Phendimetrazine |
|
| 10 mg Cocaine with 210 mg Phendimetrazine |
|
| 20 mg Cocaine with 210 mg Phendimetrazine |
|
| 40 mg Cocaine with 210 mg Phendimetrazine |
|
| 80 mg Cocaine with 210 mg Phendimetrazine |
|
|
| 40 mg Cocaine with 0 mg Phendimetrazine |
|
| 80 mg Cocaine with 0 mg Phendimetrazine |
|
| 0 mg Cocaine with 70 mg Phendimetrazine |
|
| 10 mg Cocaine with 70 mg Phendimetrazine |
|
| 20 mg Cocaine with 70 mg Phendimetrazine |
|
| 40 mg Cocaine with 70 mg Phendimetrazine |
|
| 80 mg Cocaine with 70 mg Phendimetrazine |
|
| 0 mg Cocaine with 140 mg Phendimetrazine |
|
| 10 mg Cocaine with 140 mg Phendimetrazine |
|
| 20 mg Cocaine with 140 mg Phendimetrazine |
|
| 40 mg Cocaine with 140 mg Phendimetrazine |
|
| 80 mg Cocaine with 140 mg Phendimetrazine |
|
| 0 mg Cocaine with 210 mg Phendimetrazine |
|
| 10 mg Cocaine with 210 mg Phendimetrazine |
|
| 20 mg Cocaine with 210 mg Phendimetrazine |
|
| 40 mg Cocaine with 210 mg Phendimetrazine |
|
| 80 mg Cocaine with 210 mg Phendimetrazine |
|
|
| 40 mg Cocaine with 0 mg Phendimetrazine |
|
| 80 mg Cocaine with 0 mg Phendimetrazine |
|
| 0 mg Cocaine with 70 mg Phendimetrazine |
|
| 10 mg Cocaine with 70 mg Phendimetrazine |
|
| 20 mg Cocaine with 70 mg Phendimetrazine |
|
| 40 mg Cocaine with 70 mg Phendimetrazine |
|
| 80 mg Cocaine with 70 mg Phendimetrazine |
|
| 0 mg Cocaine with 140 mg Phendimetrazine |
|
| 10 mg Cocaine with 140 mg Phendimetrazine |
|
| 20 mg Cocaine with 140 mg Phendimetrazine |
|
| 40 mg Cocaine with 140 mg Phendimetrazine |
|
| 80 mg Cocaine with 140 mg Phendimetrazine |
|
| 0 mg Cocaine with 210 mg Phendimetrazine |
|
| 10 mg Cocaine with 210 mg Phendimetrazine |
|
| 20 mg Cocaine with 210 mg Phendimetrazine |
|
| 40 mg Cocaine with 210 mg Phendimetrazine |
|
| 80 mg Cocaine with 210 mg Phendimetrazine |
|
|
| 40 mg Cocaine with 0 mg Phendimetrazine |
|
| 80 mg Cocaine with 0 mg Phendimetrazine |
|
| 0 mg Cocaine with 70 mg Phendimetrazine |
|
| 10 mg Cocaine with 70 mg Phendimetrazine |
|
| 20 mg Cocaine with 70 mg Phendimetrazine |
|
| 40 mg Cocaine with 70 mg Phendimetrazine |
|
| 80 mg Cocaine with 70 mg Phendimetrazine |
|
| 0 mg Cocaine with 140 mg Phendimetrazine |
|
| 10 mg Cocaine with 140 mg Phendimetrazine |
|
| 20 mg Cocaine with 140 mg Phendimetrazine |
|
| 40 mg Cocaine with 140 mg Phendimetrazine |
|
| 80 mg Cocaine with 140 mg Phendimetrazine |
|
| 0 mg Cocaine with 210 mg Phendimetrazine |
|
| 10 mg Cocaine with 210 mg Phendimetrazine |
|
| 20 mg Cocaine with 210 mg Phendimetrazine |
|
| 40 mg Cocaine with 210 mg Phendimetrazine |
|
| 80 mg Cocaine with 210 mg Phendimetrazine |
|
|
| 40 mg Cocaine with 0 mg Phendimetrazine |
|
| 80 mg Cocaine with 0 mg Phendimetrazine |
|
| 0 mg Cocaine with 70 mg Phendimetrazine |
|
| 10 mg Cocaine with 70 mg Phendimetrazine |
|
| 20 mg Cocaine with 70 mg Phendimetrazine |
|
| 40 mg Cocaine with 70 mg Phendimetrazine |
|
| 80 mg Cocaine with 70 mg Phendimetrazine |
|
| 0 mg Cocaine with 140 mg Phendimetrazine |
|
| 10 mg Cocaine with 140 mg Phendimetrazine |
|
| 20 mg Cocaine with 140 mg Phendimetrazine |
|
| 40 mg Cocaine with 140 mg Phendimetrazine |
|
| 80 mg Cocaine with 140 mg Phendimetrazine |
|
| 0 mg Cocaine with 210 mg Phendimetrazine |
|
| 10 mg Cocaine with 210 mg Phendimetrazine |
|
| 20 mg Cocaine with 210 mg Phendimetrazine |
|
| 40 mg Cocaine with 210 mg Phendimetrazine |
|
| 80 mg Cocaine with 210 mg Phendimetrazine |
|
|
| 40 mg Cocaine with 0 mg Phendimetrazine |
|
| 80 mg Cocaine with 0 mg Phendimetrazine |
|
| 0 mg Cocaine with 70 mg Phendimetrazine |
|
| 10 mg Cocaine with 70 mg Phendimetrazine |
|
| 20 mg Cocaine with 70 mg Phendimetrazine |
|
| 40 mg Cocaine with 70 mg Phendimetrazine |
|
| 80 mg Cocaine with 70 mg Phendimetrazine |
|
| 0 mg Cocaine with 140 mg Phendimetrazine |
|
| 10 mg Cocaine with 140 mg Phendimetrazine |
|
| 20 mg Cocaine with 140 mg Phendimetrazine |
|
| 40 mg Cocaine with 140 mg Phendimetrazine |
|
| 80 mg Cocaine with 140 mg Phendimetrazine |
|
| 0 mg Cocaine with 210 mg Phendimetrazine |
|
| 10 mg Cocaine with 210 mg Phendimetrazine |
|
| 20 mg Cocaine with 210 mg Phendimetrazine |
|
| 40 mg Cocaine with 210 mg Phendimetrazine |
|
| 80 mg Cocaine with 210 mg Phendimetrazine |
|
|
| 40 mg Cocaine with 0 mg Phendimetrazine |
|
| 80 mg Cocaine with 0 mg Phendimetrazine |
|
| 0 mg Cocaine with 70 mg Phendimetrazine |
|
| 10 mg Cocaine with 70 mg Phendimetrazine |
|
| 20 mg Cocaine with 70 mg Phendimetrazine |
|
| 40 mg Cocaine with 70 mg Phendimetrazine |
|
| 80 mg Cocaine with 70 mg Phendimetrazine |
|
| 0 mg Cocaine with 140 mg Phendimetrazine |
|
| 10 mg Cocaine with 140 mg Phendimetrazine |
|
| 20 mg Cocaine with 140 mg Phendimetrazine |
|
| 40 mg Cocaine with 140 mg Phendimetrazine |
|
| 80 mg Cocaine with 140 mg Phendimetrazine |
|
| 0 mg Cocaine with 210 mg Phendimetrazine |
|
| 10 mg Cocaine with 210 mg Phendimetrazine |
|
| 20 mg Cocaine with 210 mg Phendimetrazine |
|
| 40 mg Cocaine with 210 mg Phendimetrazine |
|
| 80 mg Cocaine with 210 mg Phendimetrazine |
|
|
| 40 mg Cocaine with 0 mg Phendimetrazine |
|
| 80 mg Cocaine with 0 mg Phendimetrazine |
|
| 0 mg Cocaine with 70 mg Phendimetrazine |
|
| 10 mg Cocaine with 70 mg Phendimetrazine |
|
| 20 mg Cocaine with 70 mg Phendimetrazine |
|
| 40 mg Cocaine with 70 mg Phendimetrazine |
|
| 80 mg Cocaine with 70 mg Phendimetrazine |
|
| 0 mg Cocaine with 140 mg Phendimetrazine |
|
| 10 mg Cocaine with 140 mg Phendimetrazine |
|
| 20 mg Cocaine with 140 mg Phendimetrazine |
|
| 40 mg Cocaine with 140 mg Phendimetrazine |
|
| 80 mg Cocaine with 140 mg Phendimetrazine |
|
| 0 mg Cocaine with 210 mg Phendimetrazine |
|
| 10 mg Cocaine with 210 mg Phendimetrazine |
|
| 20 mg Cocaine with 210 mg Phendimetrazine |
|
| 40 mg Cocaine with 210 mg Phendimetrazine |
|
| 80 mg Cocaine with 210 mg Phendimetrazine |
|
|
| 40 mg Cocaine with 0 mg Phendimetrazine |
|
| 80 mg Cocaine with 0 mg Phendimetrazine |
|
| 0 mg Cocaine with 70 mg Phendimetrazine |
|
| 10 mg Cocaine with 70 mg Phendimetrazine |
|
| 20 mg Cocaine with 70 mg Phendimetrazine |
|
| 40 mg Cocaine with 70 mg Phendimetrazine |
|
| 80 mg Cocaine with 70 mg Phendimetrazine |
|
| 0 mg Cocaine with 140 mg Phendimetrazine |
|
| 10 mg Cocaine with 140 mg Phendimetrazine |
|
| 20 mg Cocaine with 140 mg Phendimetrazine |
|
| 40 mg Cocaine with 140 mg Phendimetrazine |
|
| 80 mg Cocaine with 140 mg Phendimetrazine |
|
| 0 mg Cocaine with 210 mg Phendimetrazine |
|
| 10 mg Cocaine with 210 mg Phendimetrazine |
|
| 20 mg Cocaine with 210 mg Phendimetrazine |
|
| 40 mg Cocaine with 210 mg Phendimetrazine |
|
| 80 mg Cocaine with 210 mg Phendimetrazine |
|
|
| 40 mg Cocaine with 0 mg Phendimetrazine |
|
| 80 mg Cocaine with 0 mg Phendimetrazine |
|
| 0 mg Cocaine with 70 mg Phendimetrazine |
|
| 10 mg Cocaine with 70 mg Phendimetrazine |
|
| 20 mg Cocaine with 70 mg Phendimetrazine |
|
| 40 mg Cocaine with 70 mg Phendimetrazine |
|
| 80 mg Cocaine with 70 mg Phendimetrazine |
|
| 0 mg Cocaine with 140 mg Phendimetrazine |
|
| 10 mg Cocaine with 140 mg Phendimetrazine |
|
| 20 mg Cocaine with 140 mg Phendimetrazine |
|
| 40 mg Cocaine with 140 mg Phendimetrazine |
|
| 80 mg Cocaine with 140 mg Phendimetrazine |
|
| 0 mg Cocaine with 210 mg Phendimetrazine |
|
| 10 mg Cocaine with 210 mg Phendimetrazine |
|
| 20 mg Cocaine with 210 mg Phendimetrazine |
|
| 40 mg Cocaine with 210 mg Phendimetrazine |
|
| 80 mg Cocaine with 210 mg Phendimetrazine |
|
|
| 40 mg Cocaine with 0 mg Phendimetrazine |
|
| 80 mg Cocaine with 0 mg Phendimetrazine |
|
| 0 mg Cocaine with 70 mg Phendimetrazine |
|
| 10 mg Cocaine with 70 mg Phendimetrazine |
|
| 20 mg Cocaine with 70 mg Phendimetrazine |
|
| 40 mg Cocaine with 70 mg Phendimetrazine |
|
| 80 mg Cocaine with 70 mg Phendimetrazine |
|
| 0 mg Cocaine with 140 mg Phendimetrazine |
|
| 10 mg Cocaine with 140 mg Phendimetrazine |
|
| 20 mg Cocaine with 140 mg Phendimetrazine |
|
| 40 mg Cocaine with 140 mg Phendimetrazine |
|
| 80 mg Cocaine with 140 mg Phendimetrazine |
|
| 0 mg Cocaine with 210 mg Phendimetrazine |
|
| 10 mg Cocaine with 210 mg Phendimetrazine |
|
| 20 mg Cocaine with 210 mg Phendimetrazine |
|
| 40 mg Cocaine with 210 mg Phendimetrazine |
|
| 80 mg Cocaine with 210 mg Phendimetrazine |
|
|
| 40 mg Cocaine with 0 mg Phendimetrazine |
|
| 80 mg Cocaine with 0 mg Phendimetrazine |
|
| 0 mg Cocaine with 70 mg Phendimetrazine |
|
| 10 mg Cocaine with 70 mg Phendimetrazine |
|
| 20 mg Cocaine with 70 mg Phendimetrazine |
|
| 40 mg Cocaine with 70 mg Phendimetrazine |
|
| 80 mg Cocaine with 70 mg Phendimetrazine |
|
| 0 mg Cocaine with 140 mg Phendimetrazine |
|
| 10 mg Cocaine with 140 mg Phendimetrazine |
|
| 20 mg Cocaine with 140 mg Phendimetrazine |
|
| 40 mg Cocaine with 140 mg Phendimetrazine |
|
| 80 mg Cocaine with 140 mg Phendimetrazine |
|
| 0 mg Cocaine with 210 mg Phendimetrazine |
|
| 10 mg Cocaine with 210 mg Phendimetrazine |
|
| 20 mg Cocaine with 210 mg Phendimetrazine |
|
| 40 mg Cocaine with 210 mg Phendimetrazine |
|
| 80 mg Cocaine with 210 mg Phendimetrazine |
|