Cryo Balloon for Residual Barrett's Esophagus

CryoBalloon Focal Ablation System for Residual Barretts Esophagus Post Ablation; a Pilot Study.

This study is being done to see if treating residual Barrett's Esophagus after previously having undergone Radiofrequency ablation or Endoscopic Mucosal resection can be eliminated with focal cryotherapy.

Inclusion criteria:

• Age > 18 years old
• Able to provide informed consent
• Patients with unifocal or multifocal BE with 2 cm who have failed at least 2 serial RFA or other endoscopic therapy such as Endoscopic Mucosal resection,

Exclusion criteria:

• Age younger than 18 years old
• Presence of esophageal varices
• Esophageal stricture precluding passage of an endoscope
• Inability to provide informed consent
• Esophageal cancer (T2 and above)
• Coagulopathy with INR > 2.0, thrombocytopenia with platelet counts < 50,000
• Pregnancy (if required a pregnancy test would be performed as part of routine clinical care)