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| ID | Type | Description | Link |
|---|---|---|---|
| R01HL087923 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Heart, Lung, and Blood Institute (NHLBI) | NIH |
| University of Georgia | OTHER |
| San Francisco State University | OTHER |
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This research focuses on overweight, sedentary children whose health, cognition, and academic performance are therefore at risk, and who may be particularly responsive to exercise interventions.
This study will determine whether regular exercise per se (i.e. compared to attention control, or placebo, condition) benefits children's cognition and achievement, and will provide insight into neural mechanisms. A substudy will examine exercise-induced changes in brain structure.
Provision of comprehensive evidence for the benefits of exercise on children's health may reduce barriers to vigorous physical activity programs during a childhood obesity epidemic by persuading policymakers, schools and communities that time spent in physical activity enhances, rather than detracts from, learning.
An ancillary study adding cardiometabolic outcome measures was added (R01HL087923-02S1, http://projectreporter.nih.gov/project\_info\_description.cfm?aid=7880457\&icde=20104167)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| After-school exercise program | Experimental | 40 min/day vigorous aerobic games after school |
|
| Sedentary after-school program | Active Comparator | Attention-control condition similar to experimental condition with the exception of exercise |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise | Behavioral | Heart rate monitors worn by each child at each session |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in Planning Scale scores | The Cognitive Assessment System provides an individually administered standardized psychological assessment of executive function | Baseline, 8 months, one-year follow-up |
| Change in functional MRI | Change in blood-oxygenation level dependent (BOLD) signal reflecting brain activation during executive function tasks | Baseline, 8 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in BMI | BMI and BMI z-score, per current norms, will be calculated | Baseline, 8 months, one-year follow-up |
| Change in adiposity | Percent fat via whole-body dual-energy x-ray absorptiometry |
| Measure | Description | Time Frame |
|---|---|---|
| Change in physical activity outside the program | Youth Risk Behavior Survey questions at all 3 timepoints, accelerometry at baseline and 8 months | Baseline, 8 months, one-year follow-up |
| Attendance to the interventions |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Catherine L Davis, PhD | Medical College of Georgia, Georgia Regents University | Principal Investigator |
| Jennifer E McDowell, PhD | University of Georgia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Georgia Prevention Institute | Augusta | Georgia | 30912 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23788510 | Result | Krafft CE, Schwarz NF, Chi L, Weinberger AL, Schaeffer DJ, Pierce JE, Rodrigue AL, Yanasak NE, Miller PH, Tomporowski PD, Davis CL, McDowell JE. An 8-month randomized controlled exercise trial alters brain activation during cognitive tasks in overweight children. Obesity (Silver Spring). 2014 Jan;22(1):232-42. doi: 10.1002/oby.20518. Epub 2013 Sep 10. | |
| 24096138 | Result | Krafft CE, Pierce JE, Schwarz NF, Chi L, Weinberger AL, Schaeffer DJ, Rodrigue AL, Camchong J, Allison JD, Yanasak NE, Liu T, Davis CL, McDowell JE. An eight month randomized controlled exercise intervention alters resting state synchrony in overweight children. Neuroscience. 2014 Jan 3;256:445-55. doi: 10.1016/j.neuroscience.2013.09.052. Epub 2013 Oct 3. |
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| ID | Term |
|---|---|
| D050177 | Overweight |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| After-school program | Behavioral | Supervised recreational program with token economy |
|
| Baseline, 8 months, one-year follow-up |
| Change in aerobic fitness | VO2 peak via treadmill test | Baseline, 8 months, one-year follow-up |
| Change in Tower of London scores | Individually administered standardized psychological assessment of executive function | Baseline, 8 months, one-year follow-up |
| Change in teacher ratings of classroom behavior | Behavior Rating Inventory for Executive Functions-Teacher form | Baseline, 8 months |
| Change in academic achievement | Woodcock-Johnson Test of Achievement III | Baseline, 8 months, one-year follow-up |
| Change in performance on executive function tasks | Antisaccade and flanker tasks - error rates, interference effect | Baseline, 8 months |
| 8 months |
| Average heart rate during the exercise intervention | Polar heart rate monitors will be worn by each child in the exercise intervention and downloaded after each session. Average heart rate during the session will be recorded daily. The mean for each child over the intervention period will be computed. | 8 months |
| Points earned during the intervention | Points earned for expected behavior will be recorded daily for each child that attends the intervention. Points are redeemed for small prizes weekly. | 8 months |
| 24457421 | Result | Krafft CE, Schaeffer DJ, Schwarz NF, Chi L, Weinberger AL, Pierce JE, Rodrigue AL, Allison JD, Yanasak NE, Liu T, Davis CL, McDowell JE. Improved frontoparietal white matter integrity in overweight children is associated with attendance at an after-school exercise program. Dev Neurosci. 2014;36(1):1-9. doi: 10.1159/000356219. Epub 2014 Jan 21. |
| 24797659 | Result | Schaeffer DJ, Krafft CE, Schwarz NF, Chi L, Rodrigue AL, Pierce JE, Allison JD, Yanasak NE, Liu T, Davis CL, McDowell JE. An 8-month exercise intervention alters frontotemporal white matter integrity in overweight children. Psychophysiology. 2014 Aug;51(8):728-33. doi: 10.1111/psyp.12227. Epub 2014 May 5. |
| 24949818 | Result | Schaeffer DJ, Krafft CE, Schwarz NF, Chi L, Rodrigue AL, Pierce JE, Allison JD, Yanasak NE, Liu T, Davis CL, McDowell JE. The relationship between uncinate fasciculus white matter integrity and verbal memory proficiency in children. Neuroreport. 2014 Aug 20;25(12):921-5. doi: 10.1097/WNR.0000000000000204. |
| 31094443 | Derived | Williams CF, Bustamante EE, Waller JL, Davis CL. Exercise effects on quality of life, mood, and self-worth in overweight children: the SMART randomized controlled trial. Transl Behav Med. 2019 May 16;9(3):451-459. doi: 10.1093/tbm/ibz015. |
| D012816 |
| Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |