MELATOX: Evaluation of Percutaneous Dissolvement of Melatonin When Used as Sunscreen; a Randomized, Placebo Controlled, Double-blind Crossover Study on Healthy Volunteers.

MELATOX: Evaluation of Percutaneous Dissolvement of Melatonin When Used as Sunscreen; a Randomized, Placebo Controlled, Double-blind Crossover Study on Healthy Volunteers.

The purpose of this study is to evaluate the percutaneous transportation and pharmacokinetics of melatonincream 12,5% when used on 80% of the body area. A test battery consisting of blood, saliva, urine samples at 1,2,3,4,5,6,7,8,12,24 and 36 hours after cream application. Cognitive parameters are investigated using KSS, FTT and CRT tests at above mentioned time points.

Inclusion Criteria:

• Healthy volunteers of both sexes
• Age 18-65 years
• No shiftwork
• No intake of caffeine or alcohol one day before investigation, and under the experiment.
• Pittsburgh sleep quality index <5
• Height 165-190 cm
• Weight 53-85 kg

Exclusion Criteria:

• Pregnancy
• Active skin-disease
• Use of hypnotic or sedative drugs.
• Known sleeping disorder
• Known allergy to contents of the cream.