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Due to difficulties in recruiting the subjects.
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The primary purpose of this study is to compare the effect of lidocaine and dexamethasone on postoperative quality of recovery after laparoscopic cholecystectomy
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Lidocaine group | Experimental |
| |
| Dexamethasone group | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Lidocaine | Drug | Lidocaine 2mg Kg-1 in normal saline (total volume 25mL) was infused after tracheal intubation, and lidocaine was infused at the rate of lidocaine 2mg Kg-1 h-1 (0.2 ml Kg-1 h-1, equivalent volume as normal saline in dexamethasone group) until the end of surgery (at the time of skin closure). |
| Measure | Description | Time Frame |
|---|---|---|
| QoR-40 score | 40-item quality-of-recovery scoring system | from baseline to 3 hours on the day after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence and severity of postoperative nausea and vomiting | 10 cm-visual analogue scale | from baseline to 3 hours on the day after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Time to first analgesic request | from baseline to 3 hours on the day after surgery | |
| Number of rescue pain reliever | from baseline to 3 hours on the day after surgery | |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Surgery, Yonsei University College of Medicine, Seoul, Korea | Seoul | 120-752 | South Korea |
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| Dexamethasone | Drug | Dexamethasone 8mg in normal saline (total volume 25mL) was infused after tracheal intubation, and normal saline was continuously infused at the rate of 0.2 ml Kg-1 h-1 until the end of surgery (at the time of skin closure). |
|
| Severity of postoperative pain |
10 cm-visual analogue scale |
| from baseline to 3 hours on the day after surgery |
| ID | Term |
|---|---|
| D008012 | Lidocaine |
| D003907 | Dexamethasone |
| ID | Term |
|---|---|
| D000083 | Acetanilides |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
| D000588 | Amines |
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |
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