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The purpose of this study is to explore the optimal protocol for dexmedetomidine used in children during perioperative period.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1,Normal saline,1 milliliter | Placebo Comparator | Patients will be assigned to receive intranasal normal saline 1 milliliter |
|
| Group 2,dexmedetomidine 1μg.kg-1,1 milliliter | Experimental | Patients will be assigned to receive intranasal dexmedetomidine( 1μg.kg-1) 1 milliliter |
|
| Group 3,dexmedetomidine 2μg.kg-1,1 milliliter | Experimental | Patients will be assigned to receive intranasal dexmedetomidine( 2μg.kg-1 )1 milliliter |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Normal saline,1 milliliter | Drug | Normal saline,1 milliliter, 20 minutes before anaesthetic induction |
|
| Measure | Description | Time Frame |
|---|---|---|
| Sedation-Agitation Scale | The moment of entering operating room,20 minutes before anesthesia induction,10 minutes before anesthesia inducion,the moment of anesthesia induction | |
| The pediatric anesthesia emergence delirium scale | The moment of entering operating room,and from discontinuation of inhalational anesthetics to the moment of patient's consciousness recovery,an expected average of 1 hour | |
| Anesthesia induction time | From beginning of inhalating anesthetics to the moment of intubation | |
| Anesthesia maintenance time | From the moment of intubation to the discontinuation of inhalational anesthestics | |
| Recovery time | From discontinuation of inhalational anesthestics to the moment of patient's consciousness recovery, an expected average of 1 hour | |
| Change from baseline in blood pressure during anesthesia | The moment of entering operating room,20 minutes before anesthesia induction,10 minutes before anesthesia inducion,the moment of anesthesia induction | |
| Change from baseline in heart rate during anesthesia | The moment of entering operating room,20 minutes before anesthesia induction,10 minutes before anesthesia inducion,the moment of anesthesia induction | |
| Change from baseline in respiratory rate during anesthesia | The moment of entering operating room,20 minutes before anesthesia induction,10 minutes before anesthesia inducion,the moment of anesthesia induction |
| Measure | Description | Time Frame |
|---|---|---|
| The alveolar concentration of inhalational anesthetics | the moment of anesthesia induction,the moment of intubation,before cutting skin |
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Inclusion Criteria:
Exclusion Criteria:
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| Dexmedetomidine 1 μg.kg-1,1 milliliter | Drug | Dexmedetomidine 1 μg.kg-1,1 milliliter,20 minutes before anesthesia induction |
|
| Dexmedetomidine 2μg.kg-1,1 milliliter | Drug | Dexmedetomidine 2μg.kg-1,1 milliliter,20 minutes before anesthesia induction |
|
| Anesthesia induction, 8% sevoflurane | Drug | Inhalation induction with 8% sevoflurane |
|
| Anesthesia maintenance, 2%~3% sevoflurane,fentanyl | Drug | 2%~3% sevoflurane,inhalation. fentanyl,2μg.kg-1.min-1,intravenous infusion |
|
| ID | Term |
|---|---|
| D000077149 | Sevoflurane |
| D005283 | Fentanyl |
| ID | Term |
|---|---|
| D008738 | Methyl Ethers |
| D004987 | Ethers |
| D009930 | Organic Chemicals |
| D006845 | Hydrocarbons, Fluorinated |
| D006846 | Hydrocarbons, Halogenated |
| D006838 | Hydrocarbons |
| D010880 | Piperidines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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