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| ID | Type | Description | Link |
|---|---|---|---|
| DAGZWCMC | Other Identifier | Department of Anesthesiology,Guangzhou Women and Children's Medical Center |
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Hemabate is often used for gynecological patients. Hemabate is associated with many side effects, including a burning sensation in the stomach, nausea, vomiting, diarrhea etc. It is reported that dexmedetomidine reduce gastrointestinal reaction during perioperative period. We design this clinical trial to find if dexmedetomidine can prevent the side effects of hemabate in Cesarean Section patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| placebo group | Placebo Comparator | received 20 ml intravenous physiological saline |
|
| low dose dexmedetomidine group | Experimental | received 0.5μgkg-1 intravenous dexmedetomidine (Jiang Su Heng Rui Medicine Co. Ltd, Jiangsu Province, China) diluted to 20ml with physiological saline |
|
| hemabate+high dose dexmedetomidine group | Experimental | received 1μgkg-1 intravenous dexmedetomidine (Jiang Su Heng Rui Medicine Co. Ltd, Jiangsu Province, China) diluted to 20ml with physiological saline |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| placebo | Drug | received 20 ml intravenous physiological saline The infusion were completed in 30 minutes. |
|
| Measure | Description | Time Frame |
|---|---|---|
| SpO2 Change | participants will be followed for the duration of surgery, an expected average of 2 hours | |
| systolic blood pressure and diastolic blood pressure change | participants will be followed for the duration of surgery, an expected average of 2 hours | |
| Heart rate change | participants will be followed for the duration of surgery, an expected average of 2 hours | |
| nausea | 24 h postoperatively | |
| vomiting | 24h postoperatively | |
| fever | 24h postoperatively | |
| diarrhea | 24h postoperatively | |
| headache | 24h postoperatively | |
| elevated blood pressure | 24h postoperatively | |
| chest congestion | 24h postoperatively |
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Inclusion Criteria:
gynecological patients
Exclusion Criteria:
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| ID | Term |
|---|---|
| D020927 | Dexmedetomidine |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| low dose dexmedetomidine | Drug | received 0.5μgkg-1 intravenous dexmedetomidine (Jiang Su Heng Rui Medicine Co. Ltd, Jiangsu Province, China) diluted to 20ml with physiological saline The infusion were completed in 30 minutes. |
|
| high dose dexmedetomidine | Drug | received 1μgkg-1 intravenous dexmedetomidine (Jiang Su Heng Rui Medicine Co. Ltd, Jiangsu Province, China) diluted to 20ml with physiological saline. The infusion was completed in 30 minutes |
|