The aim of the study is to assess bone geometry, bone compartment specific volumetric densities and micro-architecture as well as to evaluate non-invasive estimates of bone strength in patients with adult onset growth hormone deficiency.

Inclusion Criteria:

• Men and women diagnosed with Adult onset Growth Hormone Deficiency
• Age between 18-80
• Informed consent

Exclusion Criteria:

• Competing bone disease (e.g.. Mb. Paget, myelomatosis, osteogenesis imperfecta, osteoporosis, primary hyperparathyroidism)
• Ongoing medical treatment affecting bone metabolism (eg. osteoporosis medications)
• Ongoing pregnancy or breast feeding

Patients are all seen at the Odense University Hospital at the department of Endocrinology. All patients at the hypophysis clinic were checked and those receiving growth hormone replacement therapy were invited to participate.