Bone Structure in Patients With Adult Onset Growth Hormone Deficiency Assessed Using High Resolution Peripheral Quantitative Computed Tomography

Bone Geometry, Volumetric Density, Microarchitecture and Estimated Bone Strength Assessed by High Resolution Peripheral Quantitative Computed Tomography in Patients With Adult Onset Growth Hormone Deficiency

The aim of the study is to assess bone geometry, bone compartment specific volumetric densities and micro-architecture as well as to evaluate non-invasive estimates of bone strength in patients with adult onset growth hormone deficiency.

Inclusion Criteria:

• Men and women diagnosed with Adult onset Growth Hormone Deficiency
• Age between 18-80
• Informed consent

Exclusion Criteria:

• Competing bone disease (e.g.. Mb. Paget, myelomatosis, osteogenesis imperfecta, osteoporosis, primary hyperparathyroidism)
• Ongoing medical treatment affecting bone metabolism (eg. osteoporosis medications)
• Ongoing pregnancy or breast feeding