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| Name | Class |
|---|---|
| The Research Council of Norway | OTHER |
| Tine | INDUSTRY |
| Oslo Metropolitan University | OTHER |
| Norwegian School of Sport Sciences |
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The aim of the present study is to investigate effects of milk on body composition and muscle strength, inflammation, appetite, DNA damage/repair and PBMC whole genome transcriptomics in elderly subjects.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control drink | Placebo Comparator | An isocaloric drink to milk |
|
| Milk | Experimental | Protein enriched milk (Styrk) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Milk | Dietary Supplement | 4 dl milk will be consumed daily with breakfast and supper for 12 weeks |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in muscle mass, strength and performance | Change in muscle is mass measured by DXA. Muscle strength and performance are measured by several physical tests such as repeated chair stands, handgrip strength, step stair test and strength in legs and torso and gait speed and are considered as the clinical relevant outcomes. | Measured at baseline and after 12 weeks (end-of-study visit) |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in levels of inflammatory markers | Changes in levels of inflammatory markers in circulation and at PBMC gene Expression Level such as i.e. CRP, IL-6, TNFa, IL-8, IL-18, ICAM, VCAM. | Measured at baseline and after 12 weeks (end-of-study visit) |
| Measure | Description | Time Frame |
|---|---|---|
| Effect on PBMC whole genome transcriptomics | Measurement of PBMC Whole genome transcriptomics will be performed. | Measured at baseline and after 12 weeks (end-of-study visit) |
| Changes in body composition (including bone mineral density) |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Kirsten Holven, Professor | Institute of Basic Medical Sciences, Faculty of medicine, University of Oslo | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Oslo | Oslo | Post Box 1046, Blindern | 0317 | Norway |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31798754 | Derived | Gjevestad GO, Holven KB, Rundblad A, Flatberg A, Myhrstad M, Karlsen K, Mutt SJ, Herzig KH, Ottestad I, Ulven SM. Increased protein intake affects pro-opiomelanocortin (POMC) processing, immune function and IGF signaling in peripheral blood mononuclear cells of home-dwelling old subjects using a genome-wide gene expression approach. Genes Nutr. 2019 Nov 28;14:32. doi: 10.1186/s12263-019-0654-6. eCollection 2019. | |
| 29188875 |
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| ID | Term |
|---|---|
| D008892 | Milk |
| ID | Term |
|---|---|
| D001628 | Beverages |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D003611 | Dairy Products |
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| OTHER |
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| Placebo | Dietary Supplement |
|
|
Changes in body composition are measured by DXA.
| Measured at baseline and after 12 weeks (end-of-study visit) |
| Changes in the level of appetite regulatory hormones | Changes in the level of appetite regulatory hormones such as i.e. adiponectin, glucagon-like protein (GLP-1), gastric inhibitory polypeptide (GIP), ghrelin, Peptide YY (PYY) and cholecystokinin (CCK) | Measured at baseline and after 12 weeks (end-of-study visit) |
| Changes in the Lymphocyte DNA damage and repair system | Changes will be measured using Whole blood and PBMC. | Measured at baseline and after 12 weeks (end-of-study visit) |
| Derived |
| Ottestad I, Lovstad AT, Gjevestad GO, Hamarsland H, Saltyte Benth J, Andersen LF, Bye A, Biong AS, Retterstol K, Iversen PO, Raastad T, Ulven SM, Holven KB. Intake of a Protein-Enriched Milk and Effects on Muscle Mass and Strength. A 12-Week Randomized Placebo Controlled Trial among Community-Dwelling Older Adults. J Nutr Health Aging. 2017;21(10):1160-1169. doi: 10.1007/s12603-016-0856-1. |
| D005502 |
| Food |
| D019602 | Food and Beverages |