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| Name | Class |
|---|---|
| Biotechnology and Biological Sciences Research Council | OTHER |
| Unilever R&D | INDUSTRY |
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The purpose of this study is to determine the effects of an oral fructose challenge on liver adenosine triphosphate (ATP) reserves using 31P magnetic resonance spectroscopy (MRS) as a potential measure measure of liver health.
This study uses 31P spectra acquired from the liver in healthy subjects following a fructose drink to monitor ATP levels. This is also related to baseline BMI, liver glycogen and liver lipid levels
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Fructose | Experimental | Oral Fructose Challenge (75 g fructose in 500 ml water) followed by 75 minutes 31P MRS |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Fructose | Dietary Supplement | Oral Fructose Challenge (75 g fructose in 500 ml water) following overnight fast |
|
| Measure | Description | Time Frame |
|---|---|---|
| Hepatic ATP reserves following an oral fructose challenge | Monitor hepatic ATP levels following an oral fructose challenge using 31P magnetic resonance spectroscopy | 2 hours post prandial |
| Measure | Description | Time Frame |
|---|---|---|
| Correlate hepatic ATP depletion / recovery with BMI, liver lipids and liver glycogen | Measure baseline liver lipid and glycogen using magnetic resonance spectroscopy and correlate BMI, lipid and glycogen levels with rate of ATP depletion and recovery following an oral fructose challenge | 2 hours post prandial |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Luca Marciani | University of Nottingham | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Nottingham | Nottingham | Nottinghamshire | NG7 2RD | United Kingdom |
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| ID | Term |
|---|---|
| D065626 | Non-alcoholic Fatty Liver Disease |
| ID | Term |
|---|---|
| D005234 | Fatty Liver |
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
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| ID | Term |
|---|---|
| D005632 | Fructose |
| ID | Term |
|---|---|
| D006601 | Hexoses |
| D009005 | Monosaccharides |
| D000073893 | Sugars |
| D002241 | Carbohydrates |
| D007661 |
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| Ketoses |