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Human milk is the best source of enteral nutrition for the preterm infant. However during the infants first hours and days of life breastmilk from the own mother is usually not available. Until May 2012 the practice in the Neonatal Division of the Department of Pediatrics /Medical University Vienna was to start with formula feedings within the first 6 hours of life of a premature infant and switch over to breastmilk as soon it was available. In June 2012 the investigators changed this feeding regimen and started to use single donor milk of mothers of preterm infants for the first hours and days of the preterm infants life. In a prospective observational study the investigators evaluated the impact of single donor milk from preterm infants on time to full enteral feedings, gastrointestinal tolerance and NEC incidence in preterm infants with a birthweight below 1500 grams and a gestational below 32 weeks. Data will be compared with a historical control group starting with preterm formula as source of enteral nutrition. The investigators hypothesize that starting enteral nutrition with single donor milk of mothers from preterm infants with shorten time to full enteral feedings.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Preterm Single Donor Milk Group | The prospective study group = preterm single donor milk group (PSDM-Group) from June 2012 - April 2013 |
| |
| Control Group | Retrospective control group receiving no donor milk = control group from March 2011 - May 2012 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Control Group | Other | Infants received preterm formula during their first days of life until breastmilk from their own mother was available |
|
| Measure | Description | Time Frame |
|---|---|---|
| Time to full enteral feeding | Full enteral feedings are defined as an enteral inane of 135-145ml/kg/d | birth up to 40 weeks of gestation |
| Measure | Description | Time Frame |
|---|---|---|
| necrotizing enterocolitis | Necrotising enterocolitis (NEC) was defined according to the stages by Bell as proven NEC grade 2a. | birth to 40 weeks of gestation |
| Gastric residuals | Gastric residuals are a parameter for gastrointestinal tolerance and are determined every three hours before the next meal is given and are aspirated via a gastric tube Gastric residuals are measured in ml/kg per meal. Furthermore the color is documented (milky, clear, mucous, bile stained, bloody) |
| Measure | Description | Time Frame |
|---|---|---|
| body weight | body weight in gram is measured every second day. | birth to 40th week of gestation |
Inclusion Criteria:
Exclusion Criteria:
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inborn very low birth weight infants with a birthweight <1500g and a gestational age <32 weeks
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| Name | Affiliation | Role |
|---|---|---|
| Nadja Haiden, Prof.MD | Medical University of Vienna, Department of Pediatrics | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical University of Vienna | Vienna | Austria |
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| ID | Term |
|---|---|
| D007235 | Infant, Premature, Diseases |
| ID | Term |
|---|---|
| D007232 | Infant, Newborn, Diseases |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
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| ID | Term |
|---|---|
| D035061 | Control Groups |
| ID | Term |
|---|---|
| D015340 | Epidemiologic Research Design |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D012107 | Research Design |
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| Preterm Single Donor Milk Group | Other | Infants received preterm single donor milk during their first days of life until breastmilk from their own mother was available |
|
| birth to 7th day of life |
| Frequency of stool | Number of stools per day | birth until 14th day of life |
| culture positive sepsis | birth to 40th week of gestation |
| D008722 | Methods |