Sponsor terminated study

The main purpose of this study is to evaluate whether SUDOSCAN is a valid, accurate clinical device for the the determination of sweat gland function in the pediatric population.

Primary Objective: To measure sweat gland function in a pediatric population

Secondary Objective: To determine thresholds on the SUDOSCAN scale for abnormal sweat gland function in the pediatric population

Inclusion Criteria:

• Males and females ages 8 to 17 years
• Able to give assent as well as parental consent

Exclusion Criteria:

• History of type 1 or type 2 diabetes
• Chronic autoimmune condition
• Taking chronic immunosuppressive or anti-inflammatory medications
• Unable to apply palms of the hands and soles of the feet on the sensor plates during a 3 minute Sudoscan test
• Presence of hepatitis B or C
• Presence of HIV
• Presence of known neurological disorder
• Pregnancy and/or breastfeeding
• Any open wound on the soles of the feet or palms of the hands
• Participation in an ongoing clinical investigational drug trial
• Other serious medical conditions that in the opinion of the investigator, would compromise the subject's participation in the study

100 subjects will be recruited by age group, with approximately 10 subjects representative of each age between 8 and 17. Both lean and obese subjects will be included from University of Southern California's Childhood Obesity Research Center (CORC).