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The purpose of this study is to evaluate the effect of dual probiotic strains containing Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 on triglyceride and apolipoprotein A-V.
A randomized, double-blind, placebo-controlled study was conducted on 128 nondiabetic and hypertriglyceridemic (Plasma Triglyceride, 150-500 mg/dL) subjects. Over a 12 week test period, the probiotic group consumed 2g of powder daily containing dual probiotic strains, while the placebo group consumed the same without probiotics.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| probiotic group | Experimental | consumed 2g of powder daily containing dual probiotics(Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032) |
|
| placebo group | Placebo Comparator | consumed 2g of powder daily without probiotics |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| dual probiotics | Dietary Supplement | 2g of powder daily containing dual probiotics(Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032) |
|
| Measure | Description | Time Frame |
|---|---|---|
| ApoA5-1131 genotype | ApoA5-1131 T>C | at baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Fasting glucose at baseline and 12-week follow-up | Serum fasting glucose (mg/dL) | 12-week follow-up |
| Insulin at baseline and 12-week follow-up | Serum insulin (μIU/dL) |
| Measure | Description | Time Frame |
|---|---|---|
| LDL particle size at baseline and 12-week follow-up | Plasma LDL particle size (nm) | 12-week follow-up |
| Serum high-sensitivity C-reactive protein at baseline and 12-week follow-up | Serum high-sensitivity C-reactive protein (mg/dL) |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jong Ho Lee, PhD | Yonsei University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Laboratory of Clinical Nutrigenetics/Nutrigenomics | Seoul | 120-749 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26044516 | Derived | Ahn HY, Kim M, Ahn YT, Sim JH, Choi ID, Lee SH, Lee JH. The triglyceride-lowering effect of supplementation with dual probiotic strains, Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032: Reduction of fasting plasma lysophosphatidylcholines in nondiabetic and hypertriglyceridemic subjects. Nutr Metab Cardiovasc Dis. 2015 Aug;25(8):724-33. doi: 10.1016/j.numecd.2015.05.002. Epub 2015 May 14. |
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| ID | Term |
|---|---|
| D015228 | Hypertriglyceridemia |
| ID | Term |
|---|---|
| D006949 | Hyperlipidemias |
| D050171 | Dyslipidemias |
| D052439 | Lipid Metabolism Disorders |
| D008659 | Metabolic Diseases |
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| ID | Term |
|---|---|
| D019936 | Probiotics |
| ID | Term |
|---|---|
| D019587 | Dietary Supplements |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
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|
| placebo | Dietary Supplement | 2g of powder daily without probiotics |
|
| 12-week follow-up |
| C-peptide at baseline and 12-week follow-up | Serum C-peptide (μEq/L) | 12-week follow-up |
| Apolipoprotein A-V at baseline and 12-week follow-up | Plasma apolipoprotein A-V (ng/mL) | 12-week follow-up |
| Triglyceride at baseline and 12-week follow-up | Serum triglyceride (mg/dL) | 12-week follow-up |
| Free fatty acid at baseline and 12-week follow-up | Serum free fatty acid (μEq/L) | 12-week follow-up |
| 12-week follow-up |
| D009750 |
| Nutritional and Metabolic Diseases |
| D019602 |
| Food and Beverages |