Dexmedetomidine for Postoperative Analgesia After Bariatric Surgery

Intraoperative Dexmedetomidine Versus Morphine for Postoperative Analgesia After Laparoscopic Bariatric Surgery

The purpose of this study is to determine if Dexmedetomidine given at the end of surgery will reduce postoperative morphine consumption and improve postoperative quality of recovery as compared to morphine in patients undergoing laparoscopic bariatric surgery.

effect of Dexmedetomidine bolus on postoperative morphine requirements

Inclusion Criteria:

• Body Mass Index > 40 kg/m2 or BMI > 35 kg/m2 with comorbid conditions such as hypertension, diabetes or sleep apnea
• American Society of Anesthesiologists class I or II
• Undergoing laparoscopic sleeve gastrectomy bariatric surgery

Exclusion Criteria:

• Allergy to morphine or its derivatives
• Allergy to α-2 adrenergic agonists
• weight over 180 kg
• history of uncontrolled hypertension
• heart block greater than first degree
• prolonged QT interval
• clinically significant neurologic, cardiovascular, renal, hepatic, or gastrointestinal diseases
• received an opioid analgesic medication within a 24 h period prior to surgery
• history of alcohol, drug abuse or chronic opioid intake
• history of psychiatric disorder
• pregnant or breastfeeding.