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The purpose of this study is to evaluate the relative contribution of head- and trunk-based sensory systems to internal estimates of direction of gravity in healthy human subjects. To implement this assessment experimentally, the investigators will use a motor-driven 3D-turntable and a thermoplastic mask to keep the head in a stable, either roll-tilted (±30°) or aligned with the trunk. The investigators will then obtain measurements of the subjective visual vertical in seven different whole-body roll positions (max. 90° roll-tilt). Analysis will be driven by a state-of-the art Bayesian integration model. The investigators hypothesize that different sensory input signals are combined in a statistically optimal fashion.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Vestibular stimulation | Experimental | This is the experimental paradigm applied in all participants |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vestibular stimulation by use of the turntable (static roll-tilt while the head is roll-tilted relative to the trunk) | Other |
| ||
| Measure | Description | Time Frame |
|---|---|---|
| Accuracy and precision of SVV adjustments in different head and trunk roll-tilt positions | During the turntable measurement (90 minutes) |
| Measure | Description | Time Frame |
|---|---|---|
| relative contribution of head- and trunk-based sensory systems based on Bayesian modelling | while on the turntable (1.5 hours) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Dominik Straumann, Prof, MD | University Hospital Zurich, Dept. of Neurology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital Zurich, Dept. of Neurology | Zurich | Canton of Zurich | 8091 | Switzerland |
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| 3D-video-head impulse testing |
| Other |
Evaluation of semicircular canal function. This intervention is part of the screening to determine suitability for this study |
|
| Vestibular-evoked myogenic potentials (VEMPs) | Other | Evaluation of otolith function. This intervention is part of the screening to determine suitability for this study |
|
| ID | Term |
|---|---|
| D000072458 | Orientation, Spatial |
| ID | Term |
|---|---|
| D013037 | Spatial Behavior |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D058585 | Vestibular Evoked Myogenic Potentials |
| ID | Term |
|---|---|
| D019054 | Evoked Potentials, Motor |
| D005071 | Evoked Potentials |
| D000071080 | Cortical Excitability |
| D055724 | Electrophysiological Phenomena |
| D010829 | Physiological Phenomena |
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