Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The aim of the study 'Live - without diabetes' is to investigate the effects of increased physical activity on a daily basis with or without (high intense interval training) HIIT (short and intense: 3 minutes per week) during 12 weeks in risk individuals with pre-diabetes
A total of 125 individuals with pre-diabetes will be included and randomized into four different groups (N=25, each group): 1) Increased daily activity detected by the pedometer, 2) increased daily activity detected by the pedometer + HIIT, 3) HIIT, and 4) increased daily activity detected by the pedometer + group intervention 5) a control group (maintain unchanged activity and life-style during the duration of the study).
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High intense interval training (HIIT) | Experimental | 3 x 20 sec, 3 x week |
|
| Increased daily activity detected by the pedometer | Experimental | 10.000 steps a day |
|
| Increased daily activity detected by te pedometer+HIIT | Experimental | 10.000 steps + 3 x 20 sec, 3 x week |
|
| Increased daily activity (pedometer)+group intervention | Experimental | 10.000 steps + group intervention |
|
| Control group | No Intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High intense interval training | Behavioral |
| ||
| Increased daily activity detected by the pedometer |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in insulin sensitivity | The primary endpoint is insulin sensitivity, and it will be assessed by changes in the area under the curve from baseline to end-of-study assessed by the Cederholm Index and Matsuda Index | At baseline and after 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in oxygen peak oxygen uptake | Assessed from a physical fitness test (VO2peak) | At baseline and after 12 weeks |
| Changes in glycaemic control | Measured as fasting plasma glucose, HbA1c |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Center for Diabetes Research, Gentofte Hospital | Hellerup | 2900 | Denmark |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Behavioral |
|
| Increased daily activity detected by the pedometer+HIIT | Behavioral |
|
| Increased daily activity detected by the pedometer+group intervention | Behavioral |
|
| At baseline and after 12 weeks |
| Changes in key proteins in glucose and fat metabolism (Skeletal muscle) | Expression/content of key proteins in skeletal muscle tissure (AU units) | At baseline and after 12 weeks |
| Changes in body weight (kg) | Measured by Dual-energy X-ray Absorptiometry, DXA | At baseline and after 12 weeks |
| Changes in key proteins in glucose and fat metabolism (Adipose fat tissure) | Expression/content of key proteins in adipose tissue (AU units) | At baseline and after 12 weeks |
| Patient-reported outcome measure | Health related quality of life measured from Short Form 36 (SF36). Where scores are presented as norm-based scores (0-100) with higher scores indicating better perceived health status. | At baseline and after 12 weeks |