Using Spectrally Encoded Confocal Microscopy (SECM) to Visualise the Esophagus Using an SECM Probe

Pilot Study to Image the Esophagus Using a SECM Probe

The study is being done to test the feasibility and tolerability of a SECM imaging probe in patients with Barrett's Esophagus (BE).

Subjects will undergo SECM probe imaging while they are under conscious sedation. Spiral SECM imaging will be performed continuously over a pre-determined length. Patients will later be asked for their feedback.

Subjects with a previous diagnosis of Barrett's Esophagus will be recruited in the study and undergo SECM probe imaging while using conscious sedation, pulse oximetry and blood pressure monitoring. The probe will be inserted the predetermined required distance in the esophagus using a guide wire.

Once the SECM imaging probe is in place, spiral SECM image data will be continuously collected over a pre-determined length (approximately 5cm).

Inclusion Criteria:

• A previous diagnosis of Barrett's Esophagus
• Patients must be over the age of 18
• Patient must be able to give informed consent

Exclusion Criteria:

• Subjects with any history of intestinal strictures
• OR subjects with a history of prior GI surgery
• OR subjects with a history of intestinal Crohn's disease.