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The study hypothesis is that for people with moderate to severe multiple sclerosis postural balance and walking improve and the risk of accidental falls are reduced after participating in a specific training intervention of 7 weeks. The hypothesis is also the the effect remain a further 7 weeks post training.
Multiple Sclerosis (MS) is disease affecting the central nervous system. Walking and postural balance are often affected early in the course of the disease. The risk of falls is large. Many persons with MS have decreased trunk stability compared to healthy persons . In an earlier study including people with mild to moderate MS we found that a period of core stability exercises reduced the risk of falls. In this study the training concept will be applied for persons with more severe walking limitations.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group balance training late start | No Intervention | Participants randomized to late start act as No intervention group during the study period. | |
| Group balance training early start | Experimental | Group balance training focusing on core stability exercises 2 times per week for 7 weeks and 2 home training sessions per weeks. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Group balance training | Other | Group balance training 60 minutes 2 times per week plus 3-5 home exercises 2 times/week. Exercises focus om core stability in sitting, standing and lying. |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in Berg Balance Scale at 8 weeks | baseline, 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline in 10 repetitions Sit to stand test at 15 weeks | baseline, 15 weeks | |
| Change from baseline in Trunk Impairment scale at 8 weeks | baseline, 8 weeks | |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Anna Carling, MSc | Centre for Health Care Sciences, Örebro County Council | Principal Investigator |
| Anette Forsberg, PhD | Family Medicine Research Centre, Örebro County Council | Study Chair |
| Ylva Nilsagård, PhD | Centre for Health Care Sciences, Örebro County Council | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Neurorehab Mälarsjukhuset | Eskilstuna | Sweden | ||||
| Physiotherapy department Gävle hospital |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25004466 | Background | Nilsagard YE, von Koch LK, Nilsson M, Forsberg AS. Balance exercise program reduced falls in people with multiple sclerosis: a single-group, pretest-posttest trial. Arch Phys Med Rehabil. 2014 Dec;95(12):2428-34. doi: 10.1016/j.apmr.2014.06.016. Epub 2014 Jul 6. |
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| ID | Term |
|---|---|
| D009103 | Multiple Sclerosis |
| ID | Term |
|---|---|
| D020278 | Demyelinating Autoimmune Diseases, CNS |
| D020274 | Autoimmune Diseases of the Nervous System |
| D009422 | Nervous System Diseases |
| D003711 | Demyelinating Diseases |
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| Change from baseline in the Trunk Impairment Scale at 15 weeks |
| baseline, 15 weeks |
| Change from baseline in the 10 repetition Si to stand test at 8 weeks | baseline, 8 weeks |
| Change from baseline in the Berg Balance scale at 15 weeks | baseline, 15 weeks |
| Change from baseline on the Timed Up and Go test at 8 weeks | baseline, 8 weeks |
| Change from baseline on the Timed Up and Go test at 15 weeks | baseline, 15 weeks |
| Change from baseline on the10 meter walking test at 8 weeks | baseline, 8 weeks |
| Change from baseline on the 10 meter walking test at 15 weks | baseline, 15 weeks |
| Change from baseline on the 2 minutes walking test at 8 weeks | baseline, 8 weeks |
| Change from baseline on the 2 minutes walking test at 15 weeks | baseline, 15 weeks |
| Change from baseline in postural sway at 8 weeks | baseline, 8 weeks |
| Change from baseline in postural sway at 15 weeks | postural sway in standing on the floor is assessed | baseline, 15 weeks |
| Change from baseline on the Falls-Efficacy scale at 8 weeks | baseline, 8 weeks |
| Change from baseline on the Falls Efficacy scale at 15 weeks | baseline, 15 weeks |
| Change from baseline on the Fatigue Scale for Motor and Cognitive functions at 8 weeks | baseline, 8 weeks |
| Change from baseline on the Fatigue Scale for Motor and Cognitive functions at 15 weeks | baseline, 15 weeks |
| Change from baseline on the MS Walking Scale-12 at 8 weeks | baseline, 8 weeks |
| Change from baseline on the MS Walking scale-12 at 15 weeks | baseline, 15 weeks |
| The number of falls and accidental falls | the number of falls and accidental falls are noted by the participant in a study-specific falls diary. | from baseline to 15 weeks |
| Gävle |
| Sweden |
| Rehab unit Karlskoga hospital | Karlskoga | Sweden |
| Primary Health Care | Linköping | Sweden |
| Nyköping hospital | Nyköping | Sweden |
| Physiotherapy department University hospital | Örebro | Sweden |
| Rehab unit Västerås hospital | Västerås | Sweden |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |