Weight Loss-Independent Metabolic Effects of Roux-En-Y Gastric Bypass in Diabetes

Weight Loss-Independent Metabolic Effects of Roux-En-Y Gastric Bypass in Diabetes

For this purpose, we will compare the effects of targeted 16-18% (with a range of 16-25%) weight loss induced by Roux-en-Y Gastric bypass (RYGB) surgery with the same weight loss induced by a low-calorie diet (LCD) on liver and skeletal muscle insulin sensitivity, beta-cell function, and 24-hour metabolic homeostasis in obese subjects with or without T2D.

Inclusion Criteria:

For RYGB group:

• Scheduled for this bariatric surgery
• Body Mass Index (BMI) 34-55 kg/m²
• Type 2 Diabetes
• Signed informed consent

For Low-Calorie Diet group:

• BMI 34-55 kg/m²
• Type 2 Diabetes and Non-Diabetics
• Signed informed consent

Exclusion Criteria:

For both RYGB & Low-Calorie Diet groups

• Regular use of tobacco products
• Previous intestinal resection
• Pregnant or breastfeeding
• Evidence of significant organ system dysfunction or disease other than T2D
• Use of any medication that might, in the opinion of the investigator, affect metabolic function
• Exercise ≥90 minutes per week