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High mobility group 1 (HMGB1) protein is both a nuclear factor and a secreted protein, and has recently been identified as a cytokine mediator of systemic inflammation. HMGB1 is released by inflammatory cells actively, or increased during cell death passively and mediates inflammatory response. It has been reported to have association with the prognosis after acute coronary syndrome, ischemia-reperfusion injury of myocardium, atherosclerosis and heart failure. This study aimed to investigate the relationship of serum levels of HMGB1 and post operative prognosis of patients who had undergone off-pump coronary artery bypass graft.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HMGB1 group |
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| Measure | Description | Time Frame |
|---|---|---|
| Maximum value of HMGB1 | Measure the maximum value of HMGB1 in all patients and calculate median value. And device into upper median value group and under median value group and compare frequency of composite morbidity/mortality rate between two groups. composite morbidity/mortality is as follows:
| Change from induction of anesthesia to 2hrs after transfer to intensive care unit |
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Inclusion Criteria:
Exclusion Criteria:
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Patients over age 20 who are undergoing off-pump coronary artery bypass graft
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Anesthesiology & Pain Medicine, Yonsei university college of medicine | Seoul | 120-752 | South Korea |
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