Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Postoperative pain following tonsillectomy or adeno-tonsillectomy in children is severe and sometimes last for days. Sufentanil is used by epidural route for postoperative analgesia in children. There are few reports about its use for postoperative analgesia by continuous intravenous infusion. Its complications include , hypoxia, sedation, pruritus ,nausea and/or vomiting.
The investigators design this protocol to test efficacy of analgesia of three different rates of continuous intravenous sufentanil infusion for postoperative pain management following coblation tonsillectomy or adeno-tonsillectomy in children. The investigators also compare incidence rate of complications for three groups.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sufentanil infusion rate 0.02μg•kg-1•h-1 | Experimental | Sufentanil infusion rate 0.02μg•kg-1•h-1 lasted for 48 hours |
|
| Sufentanil infusion rate 0.03μg•kg-1•h-1 | Experimental | Sufentanil infusion rate 0.03μg•kg-1•h-1 lasted for 48 hours |
|
| Sufentanil infusion rate 0.04μg•kg-1•h-1 | Experimental | Sufentanil infusion rate 0.04μg•kg-1•h-1 lasted for 48 hours |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| continuous intravenous sufentanil 0.02μg•kg-1•h-1 infusion | Drug |
| ||
| continuous intravenous sufentanil 0.03μg•kg-1•h-1 infusion |
| Measure | Description | Time Frame |
|---|---|---|
| objective pain score | up to 48 hours after operation |
| Measure | Description | Time Frame |
|---|---|---|
| incidence rate of hypoxia | 4h,8h,24h,48h after operation |
| Measure | Description | Time Frame |
|---|---|---|
| incidence rate of pruritus | 4h,8h,24h,48h after operation | |
| incidence rate of nausea and/or vomiting | 4h,8h,24h,48h after operation | |
| incidence rate of sedation |
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Jin Ni, M.D. | Guangzhou Women and Children's Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Guangzhou Women and Children's Medical Center | Guangzhou | Guangdong | 510623 | China |
Not provided
Not provided
Not provided
Not provided
Not provided
| Drug |
|
| continuous intravenous sufentanil 0.04μg•kg-1•h-1 infusion | Drug |
|
| 4h,8h,24h,48h after operation |
| ID | Term |
|---|---|
| D014069 | Tonsillitis |
| ID | Term |
|---|---|
| D010612 | Pharyngitis |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D010608 | Pharyngeal Diseases |
| D009057 | Stomatognathic Diseases |
| D012140 | Respiratory Tract Diseases |
| D010038 | Otorhinolaryngologic Diseases |
Not provided
Not provided