Study to Image the Esophagus Using the OFDI Capsule

Pilot Study for Imaging of the Esophagus Using an OFDI Capsule

The main purpose of this research is to test the feasibility and tolerability of the tethered capsule Optical Frequency Domain Imaging (OFDI)

A total of 56 subjects with Barrett's Esophagus, EoE and healthy volunteers will be asked to swallow the OFDI capsule while being unsedated. The capsule is attached to a tether that allows the capsule operator to navigate the capsule as it progresses down the esophagus using natural propulsion called peristalsis as well as to bring it back up to pulled out of the mouth when the procedure is done.

As the capsule progresses down the esophagus, multiple, two dimensional, microscopic cross- sectional images of the esophagus are acquired.

Inclusion Criteria:

• A previous diagnosis of Barrett's Esophagus
• OR a previous diagnosis of EoE
• OR a previous diagnosis of Gastroesophageal reflux disease (GERD)
• Subject must be 18 years or older in case of Barrett's and GERD, and over the age of 16 years for EoE
• Subject must be able to give informed consent

Exclusion Criteria:

• Subjects with known esophageal strictures, intestinal strictures or dysphagia
• OR subjects with a history of prior GI surgery or GI Intestinal Crohn's disease