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| Name | Class |
|---|---|
| National Evidence-Based Healthcare Collaborating Agency | OTHER_GOV |
| Asan Medical Center | OTHER |
| Samsung Medical Center | OTHER |
| Severance Hospital |
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This clinical trial is aimed to show a procalcitonin-guided treatment algorithm may shorten duration of antibiotic therapy safely and cost-effectively in sepsis patients of Korean ICU.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Procalcitonin guided treatment | Experimental | Patients who will be randomized to this arm will receive antibiotics therapy based on procalcitonin-guided algorithm. |
|
| Conventional treatment | Active Comparator | Patients who will be randomized to this arm will receive antibiotic therapy based on conventional practice. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Procalcitonin guided treatment | Other | Patients who will be randomized to arm will receive antibiotics therapy based on procalcitonin measurement on day 1, 3, 5, 7, 9, 11 and 13. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Duration of antibiotic treatment | up to 28 days |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical response to treatment for infection | success vs failure vs relapse after treatment | up to 28 days |
| In ICU mortality | up to 28 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sang-Min Lee, M.D. | Seoul National University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Seoul | 110-744 | South Korea | |||
| Samsung Medical Center |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30977312 | Derived | Jeon K, Suh JK, Jang EJ, Cho S, Ryu HG, Na S, Hong SB, Lee HJ, Kim JY, Lee SM. Procalcitonin-Guided Treatment on Duration of Antibiotic Therapy and Cost in Septic Patients (PRODA): a Multi-Center Randomized Controlled Trial. J Korean Med Sci. 2019 Apr 15;34(14):e110. doi: 10.3346/jkms.2019.34.e110. |
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| ID | Term |
|---|---|
| D018805 | Sepsis |
| ID | Term |
|---|---|
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
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| OTHER |
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| Conventional treatment | Other | Patients who will be randomized to this arm will receive antibiotic therapy based on conventional practice. |
|
| All cause mortality | up to 28 days |
| In hospital mortality | up to 90 days |
| Seoul |
| 135-710 |
| South Korea |
| Asan Medical Center | Seoul | South Korea |
| Severance Hospital | Seoul | South Korea |
| D013568 |
| Pathological Conditions, Signs and Symptoms |