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| ID | Type | Description | Link |
|---|---|---|---|
| 2013-A01023-42 | Other Identifier | IDRCB |
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This study aims at evaluating the myocardial triglyceride content and cardiac structure and function, using 1H magnetic resonance spectroscopy and cardiac magnetic resonance imaging, in patients with Cushing's syndrome before and after treatment and in age-, sex- and BMI-matched healthy volunteers. The investigators make the hypothesis that Cushing's syndrome patients compared to healthy subjects present with excess lipid storage in cardiac myocytes, reversible upon correction of hypercortisolism.
Despite skeletal muscle atrophy, Cushing's syndrome patients have an increased Left Ventricular mass, reversible upon correction of the hypercortisolism. This may be due to cardiac steatosis, previously demonstrated in patients with diabetes mellitus. This study aims at evaluating the myocardial triglyceride content and cardiac structure and function, using 1H magnetic resonance spectroscopy and cardiac magnetic resonance imaging (CMRI), in patients with Cushing's syndrome and in age-, sex- and BMI-matched healthy volunteers. The patients will be stratified into two groups in function of the presence or absence of diabetes mellitus or impaired glucose and will be evaluated twice: before and 6 months after efficient treatment of Cushing's syndrome. We make the hypothesis that Cushing's syndrome patients compared to healthy subjects have excess lipid storage in cardiac myocytes irrespectively of the glucose homeostasis status, and that this lipid content will decrease after the correction of hypercortisolism.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1 : 1H magnetic resonance spectroscopy and CMRI | Experimental | Group 1 : Cushing's syndrome patients with diabetes mellitus or glucose intolerance |
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| Group 2 : 1H magnetic resonance spectroscopy and CMRI | Experimental | Group 2: Cushing's syndrome patients with normal glucose intolerance |
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| Group 3 : 1H magnetic resonance spectroscopy and CMRI | Experimental | age-, sex- and BMI-matched healthy volunteers |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 1H magnetic resonance spectroscopy and CMRI | Other | Metabolic status of the patients evaluated by an OGTT (measuring plasma glucose, insulin and plasma nonesterified fatty acids concentrations) and myocardial Imaging and spectroscopy will be performed before and 6 month after treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Left Ventricular (LV) intramyocardial triglyceride / water ratio LV intramyocardial triglyceride / water ratio | Intramyocardial triglyceride content will be assessed by 1H magnetic resonance spectroscopy | Assessed twice in patients - before and 6 months after treatment - and once in volunteers |
| Measure | Description | Time Frame |
|---|---|---|
| Left Ventricular intramyocardial fatt fraction (Dixon) | In/Out of Phase Imaging (Dixon) | Assessed twice in patients - before and 6 months after treatment - and once in volunteers |
| Subcutaneous and visceral abdominal fatt |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Philippe CHANSON, MD, PhD | Contact | +33 (0)1 45 21 37 05 | philippe.chanson@bct.aphp.fr | |
| Peter KAMENICKY, MD | Contact | +33 (0)1 45 21 37 06 | peter.kamenicky@bct.aphp.fr |
| Name | Affiliation | Role |
|---|---|---|
| Philippe CHANSON, MD, PhD | AP-HP, Bicêtre Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| AP-HP, Bicêtre Hospital | Recruiting | Le Kremlin-Bicêtre | 94275 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34333603 | Derived | Wolf P, Marty B, Bouazizi K, Kachenoura N, Piedvache C, Blanchard A, Salenave S, Prigent M, Jublanc C, Ajzenberg C, Droumaguet C, Young J, Lecoq AL, Kuhn E, Agostini H, Trabado S, Carlier PG, Feve B, Redheuil A, Chanson P, Kamenicky P. Epicardial and Pericardial Adiposity Without Myocardial Steatosis in Cushing Syndrome. J Clin Endocrinol Metab. 2021 Nov 19;106(12):3505-3514. doi: 10.1210/clinem/dgab556. |
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| ID | Term |
|---|---|
| D004700 | Endocrine System Diseases |
| D003480 | Cushing Syndrome |
| ID | Term |
|---|---|
| D000308 | Adrenocortical Hyperfunction |
| D000307 | Adrenal Gland Diseases |
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| ID | Term |
|---|---|
| D007854 | Lead |
| D000359 | Aftercare |
| D000098432 | Detection Algorithms |
| ID | Term |
|---|---|
| D019216 | Metals, Heavy |
| D004602 | Elements |
| D007287 | Inorganic Chemicals |
| D008670 | Metals |
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| 1H magnetic resonance spectroscopy and CMRI | Other | Metabolic status of the patients evaluated by an OGTT (measuring plasma glucose, insulin and plasma nonesterified fatty acids concentrations) and myocardial Imaging and spectroscopy will be performed before treatment |
|
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ISubcutaneous and visceral abdominal fat masses were determined from abdominal axial images at the L3 to L4 level
| Assessed twice in patients - before and 6 months after treatment - and once in volunteers |
| Cardiac morphology and function | LV mass index, LA, LV and Right Ventricular (RV) ejection fractions and LV and RV stroke volumes assessed by Cardiac Magnetic Resonance Imaging (CMRI) | Assessed twice in patients - before and 6 months after treatment - and once in volunteers |
| D003266 |
| Continuity of Patient Care |
| D005791 | Patient Care |
| D013812 | Therapeutics |
| D006296 | Health Services |
| D005159 | Health Care Facilities Workforce and Services |
| D011320 | Primary Health Care |
| D003191 | Comprehensive Health Care |
| D010346 | Patient Care Management |
| D006298 | Health Services Administration |
| D000465 | Algorithms |
| D055641 | Mathematical Concepts |