The Safety and Efficacy of Pemetrexed Rechallenge With Bevacizumab

The Safety and Efficacy of Pemetrexed Rechallenge With Bevacizumab for Patients With Advanced Non-squamous Non-small Cell Lung Cancer

For patients with nonsquamous NSCLC and a good performance status (PS), pemetrexed and cisplatin has been recommended for first-line NSCLC treatment. Recently, results from the PARAMOUNT trial showed that patients with nonsquamous NSCLC who had a good PS and had not progressed after completing four cycles of pemetrexed-cisplatin induction therapy benefitted from pemetrexed continuation maintenance therapy. Furthermore, pemetrexed with bevacizumab continuous maintenance might be better treatment option, considering the results from AVAPEARL trial. Pemetrexed rechallenge has been reported to be effective in some patients. Therefore, in order to investigate the safety and efficacy of pemetrexed rechallenge with bevacizumab,we conducted this study.

Inclusion Criteria:

• 20 Years and older
• PS0-2
• Advanced non-squamous non-small cell lung cancer; AND
• Patients who have received more than 4 cycles of pemetrexed therapy before the study

Exclusion Criteria:

• Interstitial pneumonia; AND
• Abnormal blood test