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The purpose of this study is to determine the influence of moderate FiO2 and the lung protective ventilation on postoperative pulmonary complications following hepatic resection surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| FiO2 80%,Nonprotective Lung Ventilation | No Intervention | ||
| FiO2 30%,Nonprotective Lung Ventilation | Experimental | FiO2 30%,Nonprotective Lung Ventilation |
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| FiO2 80%,protective Lung Ventilation | Experimental | FiO2 80% and protective Lung Ventilation |
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| FiO2 30%,protective Lung Ventilation | Experimental | FiO2 30% and protective Lung Ventilation |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Moderate FiO2 and Protective Lung Ventilation Using | Other |
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| Measure | Description | Time Frame |
|---|---|---|
| a composite of pulmonary and extrapulmonary complications occurring by day 7 after surgery. | The primary outcome was a composite of major pulmonary complications (defined as pneumonia or need for invasive or noninvasive ventilation for acute respiratory failure) and extrapulmonary complications (defined as sepsis, septic shock, or death) within the first 7 days after surgery. | during the first seven days after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| incidence of pulmonary complications | the incidence of pulmonary complications due to any cause, graded on a scale from 0 (no pulmonary complications) to 4 (the most severe complications);extrapulmonary complications; durations of ICU and hospital stays; | within the 30-day follow-up period |
| Oxidative stress markers |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Fenmei Shi, M.M. | Contact | shifenmei2006@163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| First Affiliated Hospital, Sun Yat-Sen University | Recruiting | Guangzhou | Guangdong | China |
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Oxidative stress markers variation in blood before anesthesia,during and after surgery , and compare with controls. |
| 2 days |