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The triple antibiotic paste is widely used in young permanent teeth and permanent teeth root canal therapy with excellent antiantimicrobial effect.We hypothesize that its application in the treatment of periapical periodontitis of deciduous teeth is superior to other drugs currently in use as creosote.
We design to collect a group of patients presenting primary teeth with periapical periodontitis in certain criterion. We will divide the patients into two groups randomly.One group will get treated with triple antibiotic paste while the other with creosote.We want to evaluate the short-term and long-term effects of the two groups to get a conclusion of the clinical value of triple antibiotic paste.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| creosote | Active Comparator | Creosote ，once，three weeks Triple Antibiotic Paste ，none |
|
| Triple Antibiotic Paste | Experimental | Triple Antibiotic Paste,once,three weeks creosote,none |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Metronidazole-Ciprofloxacin gatifloxacin-Clindamycin paste | Drug | Pulp removal,Root canal irrigation and disinfection, |
|
| Measure | Description | Time Frame |
|---|---|---|
| Evidence of lesion healing confirmed by cone beam computed tomography and X-rays | 1 year |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jiacheng Lin | Guanghua hospital of stomotology,Sun Yat-sen University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Jicheng Lin | Guangzhou | Guangdong | 510055 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23772873 | Background | Bezgin T, Yilmaz AD, Celik BN, Sonmez H. Concentrated platelet-rich plasma used in root canal revascularization: 2 case reports. Int Endod J. 2014 Jan;47(1):41-9. doi: 10.1111/iej.12144. Epub 2013 Jun 17. | |
| 24767551 | Background | Nagata JY, Gomes BP, Rocha Lima TF, Murakami LS, de Faria DE, Campos GR, de Souza-Filho FJ, Soares Ade J. Traumatized immature teeth treated with 2 protocols of pulp revascularization. J Endod. 2014 May;40(5):606-12. doi: 10.1016/j.joen.2014.01.032. Epub 2014 Mar 6. |
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| ID | Term |
|---|---|
| D010483 | Periapical Diseases |
| D010485 | Periapical Periodontitis |
| ID | Term |
|---|---|
| D007571 | Jaw Diseases |
| D009057 | Stomatognathic Diseases |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
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| ID | Term |
|---|---|
| D003407 | Creosote |
| ID | Term |
|---|---|
| D003408 | Cresols |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
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| creosote | Drug | Pulp removal,Root canal irrigation and disinfection |
|
|
| 24862703 | Background | Nagata JY, Soares AJ, Souza-Filho FJ, Zaia AA, Ferraz CC, Almeida JF, Gomes BP. Microbial evaluation of traumatized teeth treated with triple antibiotic paste or calcium hydroxide with 2% chlorhexidine gel in pulp revascularization. J Endod. 2014 Jun;40(6):778-83. doi: 10.1016/j.joen.2014.01.038. Epub 2014 Apr 29. |
| D010518 |
| Periodontitis |
| D006844 |
| Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |