TEOSYAL® RHA GA = TEOSYAL® RHA Global Action TEOSYAL® RHA DL = TEOSYAL® RHA Deep Lines WSRS (Wrinkle Severity Rating Scale) is a validated 5-point scale assessing wrinkle severity with 1 being 'absent' and 5 being 'extreme' BLE = Blinded Live Evaluator

The subjects received a diary booklet and instructions for recording his/her observations of the Common Treatment Responses of the study treatments for the first 14 days after each treatment (initial, touch-up). The diary was discussed during each telephone follow-up visit. Subjects should complete the diary at approximately the same time each day (i.e., am or pm).

The subject diary captured the following Common Treatment Responses (CTR) that occur following the injection of a dermal filler; specifically, redness, pain, tenderness, firmness, swelling, lumps/bumps, bruising, itching, discoloration, and "other".

The 14-day patient CTR diary included a detailed glossary describing all signs/symptoms listed in the diary; an option was provided to rate "other" if the subject experienced a sign/symptom that is not listed.

The table presents the number of subjects experiencing at least 1 Common Treatment Response (CTR)

1 subject randomized to the GA/J cohort received injections with DL/J and was placed in the DL/J cohort for safety evaluation; So: N=75 for DL/J SAFT population and N=72 for GA/J SAFT population.

Number of patients for CTR after touch-up treatment are based on number of patients receiving Touch-up treatment (GA N=47/J-GA N=49/DL N=50/J-DL N=53)

VAS is a 100 mm Visual Analog Scale with 0 meaning no pain and 100 meaning intolerable pain

1 subject randomized to the GA/J cohort received injections with DL/J and was placed in the DL/J cohort for safety evaluation; So: N=75 for DL/J SAFT population and N=72 for GA/J SAFT population.

Number of patients after touch-up treatment are based on number of patients receiving Touch-up treatment (GA N=47/J-GA N=49/DL N=50/J-DL N=53)

TEOSYAL® RHA GA = TEOSYAL® RHA Global Action TEOSYAL® RHA DL = TEOSYAL® RHA Deep Lines WSRS (Wrinkle Severity Rating Scale) is a validated 5-point scale assessing wrinkle severity with 1 being 'absent' and 5 being 'extreme' BLE = Blinded Live Evaluator

Numbers of patients analyzed correspond to patients that have completed the visits and for which data were available (See participant flow)

TEOSYAL® RHA GA = TEOSYAL® RHA Global Action TEOSYAL® RHA DL = TEOSYAL® RHA Deep Lines WSRS (Wrinkle Severity Rating Scale) is a validated 5-point scale assessing wrinkle severity with 1 being 'absent' and 5 being 'extreme' TI = Treating Investigator

Numbers of patients analyzed correspond to patients that have completed the visits and for which data were available (See participant flow)

A responder correspond to a subject with an intra-individual improvement of at least one grade in the WSRS compared to baseline

Numbers of patients analyzed correspond to patients that have completed the visits and for which data were available (See participant flow)

A responder correspond to a subject with an intra-individual improvement of at least one grade in the WSRS compared to baseline

Numbers of patients analyzed correspond to patients that have completed the visits and for which data were available (See participant flow)

Global Aesthetic Improvement (GAI) is a subjective 5-grade scale comprised of "much improved, improved, no change, worse, and much worse" that evaluate the aesthetic improvement from baseline.

GAI was assessed using the baseline photograph. Each side of the face was assessed independently.

Numbers of patients analyzed correspond to patients that have completed the visits and for which data were available (See participant flow)

Global Aesthetic Improvement (GAI) is a subjective 5-grade scale comprised of "much improved, improved, no change, worse, and much worse" that evaluate the aesthetic improvement from baseline.

GAI was assessed using the baseline photograph. Subjects will be instructed: "Use a mirror to compare your face to the photograph provided to you and rate the degree of aesthetic improvement by using the following scale".

Each side of the face was assessed independently.

Numbers of patients analyzed correspond to patients that have completed the visits and for which data were available (See participant flow)

The FACE-Q measures the experience and outcomes of aesthetic facial procedures from the patient's perspective.

FACE-Q questionnaire is composed of 5 questions with a score linked to answers (1 being 'Not at all' and 4 being 'Extremely').

The subject was instructed as follows: "These questions ask about how you look right now. With your nasolabial folds in mind (the deep lines that run downward from the sides of your nose), in the past week, how much have you been bothered by:", and provided response.

• How deep your nasolabial fold are?
• How your nasolabial folds look when your face is relaxed (still)?
• How old your nasolabial folds make you look?
• How your nasolabial folds look when you smile?
• How your nasolabial folds look compared with other people your age? To calculate the FACE-Q, outcomes from all 5 questions were pooled and adapted to a scale to 100 units. Data were also transformed so that higher scores reflected a beneficial outcome.

Numbers of patients analyzed correspond to patients that have completed the visits and for which data were available (See participant flow)

Subjective 5-point scale with 1 being 'very satisfied' and 5 being 'very dissatisfied'

Numbers of patients analyzed correspond to patients that have completed the visits and for which data were available (See participant flow)

Numbers of patients analyzed correspond to patients that have completed the visits (See participant flow)