Investigating a Model for Acute Ischemic Pain in Humans

Investigating a Model for Acute Ischemic Pain in Humans

The pathophysiology of acute ischemic pain is not well established. The aim of the present study was to investigate acute ischemic pain in humans with a view to establish a scientific model to perform future studies. The investigators examined whether peripheral nerve damage and acute inflammation occur during short episodes of acute ischemia.

Inclusion Criteria:

• patients over 40 years
• unilateral femoral-popliteal PAD, Fontaine grade II

Exclusion Criteria:

• patients with pain at rest or other pain origin
• diabetic polyneuropathy
• deep vein thrombosis