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The effect of Internet-delivered Cognitive Behavior Therapy (ICBT) on adolescents (12 to 17 years) with Obsessive-Compulsive Disorder is studied. Participants are randomized to either ICBT or a no-treatment condition. We expect ICBT to be superior over the no-treatment condition.
The primary objective of this study is to test the efficacy of Internet-delivered cognitive behavior therapy (ICBT) for adolescents (12 - 17 years) with OCD. We aim to conduct a randomized controlled study with N = 66 participants. Participants will be randomly assigned to ICBT or a wait list condition, either lasting 12 weeks. The primary outcome measure is the Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS). Study participants will be followed up 3 and 12 months after treatment. ICBT is expected to yield significantly better symptom reduction than the wait list condition.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Internet-delivered CBT | Experimental | Participants will receive 12 weeks of internet-delivered cognitive behavior therapy with psychologist support. |
|
| Wait list | No Intervention | Participants will receive no treatment for 12 weeks. After that period participants will receive Internet-delivered Cognitive Behavior Therapy. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Internet-delivered Cognitive Behavior Therapy | Behavioral | The treatment consists of standard cognitive behavior therapy for obsessive-compulsive disorder and is delivered via an internet plattform and regular therapist contact several times per week via email and telephone. The treatment is 12 weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| Children's Yale Brown Obsessive Compulsive Scale, CY-BOCS | Change from Baseline of obsessions and compulsions after 12 weeks and at 3- and 12 months after treatment | Baseline, 12 weeks after treatment starts, 3 and 12 months after treatment has ended |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical Global Impression - Severity, CGI-S | Baseline, 12 weeks after treatment starts, 3 and 12 months after treatment has ended | |
| Clinical Global Impression - Improvement, CGI-I | Baseline, 12 weeks after treatment starts, 3 and 12 months after treatment has ended |
| Measure | Description | Time Frame |
|---|---|---|
| Measurement of homework adherence | Baseline, daily measurements until 12 weeks after baseline | |
| Number of Participants with Adverse Events | 12 weeks after baseline | |
| DNA samples (from blood and/or saliva) |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Eva Serlachius, MD, PhD | Karolinska Institutet | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Karolinska Institutet | Stockholm | 171 77 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28515196 | Derived | Lenhard F, Ssegonja R, Andersson E, Feldman I, Ruck C, Mataix-Cols D, Serlachius E. Cost-effectiveness of therapist-guided internet-delivered cognitive behaviour therapy for paediatric obsessive-compulsive disorder: results from a randomised controlled trial. BMJ Open. 2017 May 17;7(5):e015246. doi: 10.1136/bmjopen-2016-015246. | |
| 27993223 |
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| ID | Term |
|---|---|
| D009771 | Obsessive-Compulsive Disorder |
| ID | Term |
|---|---|
| D001008 | Anxiety Disorders |
| D001523 | Mental Disorders |
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| Parent Adherence EX/RP Scale, PEAS | Baseline, 6 and 12 weeks after treatment starts |
| Children's Obsessional Compulsive Inventory Revised, (CHOCI-R, Shafran et al., 2003) | Baseline, 12 weeks after treatment starts, 3 and 12 months after treatment has ended |
| Education, Work and Social Adjustment Scale - child and parent version (EWSAS) | Baseline, 12 weeks after treatment starts, 3 and 12 months after treatment has ended |
| Spence Child Anxiety Scale - Child and Parent version (SCAS-C/P, Spence, 1998 | Baseline, 12 weeks after treatment starts, 3 and 12 months after treatment has ended |
| Child Depression Inventory - Short version (CDI-S, Kovacs, 1985) | Baseline, 12 weeks after treatment starts, 3 and 12 months after treatment has ended |
| Family Accommodation Scale, Parent-Report (FAS-PR, Flessner et al., 2009) | Baseline, 12 weeks after treatment starts, 3 and 12 months after treatment has ended |
| Technology acceptance scale | Baseline, 6 and 12 weeks after treatment starts, |
| Trimbos/iMTA questionnaire for Costs associated with Psychiatric Illness - Child version (TiC-P) | Baseline, 12 weeks after treatment starts, 3 and 12 months after treatment has ended |
| EQ-5D - quality of life | Baseline, 12 weeks after treatment starts, 3 and 12 months after treatment has ended |
| Baseline |
| Lenhard F, Andersson E, Mataix-Cols D, Ruck C, Vigerland S, Hogstrom J, Hillborg M, Brander G, Ljungstrom M, Ljotsson B, Serlachius E. Therapist-Guided, Internet-Delivered Cognitive-Behavioral Therapy for Adolescents With Obsessive-Compulsive Disorder: A Randomized Controlled Trial. J Am Acad Child Adolesc Psychiatry. 2017 Jan;56(1):10-19.e2. doi: 10.1016/j.jaac.2016.09.515. Epub 2016 Oct 25. |