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| Name | Class |
|---|---|
| ChromaDex, Inc. | INDUSTRY |
The purpose of this study in to analyse the way in which the body processes Niagen (nicotinamide riboside) in healthy people. Blood and urine samples from subjects who are given a dose of Niagen will be analyzed for metabolites over the 24 hours after taking the dose.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Niagen 100mg | Experimental | 1 Niagen capsule (1 x 100 mg capsule) and 9 Placebo capsules |
|
| Niagen 300mg | Experimental | 3 Niagen capsules (3 x 100mg capsule) and 7 Placebo capsules |
|
| 1000mg Niagen | Experimental | 10 Niagen capsules (10 x 100mg capsule) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Niagen 100mg | Dietary Supplement |
| ||
| Niagen 300mg |
| Measure | Description | Time Frame |
|---|---|---|
| t1/2 (terminal half-life) | 24 hour dosing period; 3 dosing periods each separated by 7 day washout | 24 hours |
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| Measure | Description | Time Frame |
|---|---|---|
| Area under the curve (AUC(0-24h) | 24 hour dosing period; 3 dosing periods each separated by 7 day washout | 24 hours |
| AUCI (AUC to infinity) | 24 hour dosing period; 3 dosing periods each separated by 7 day washout |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Dale Wilson, MD | KGK Science Inc. | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| KGK Synergize Inc. | London | Ontario | N6A 5R8 | Canada |
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| ID | Term |
|---|---|
| C018613 | nicotinamide-beta-riboside |
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|
| Niagen 1000mg | Dietary Supplement |
|
| 24 hours |
| AUC(0-24h)/AUCI | 24 hour dosing period; 3 dosing periods each separated by 7 day washout | 24 hours |
| Maximum observed concentration (Cmax) | 24 hour dosing period; 3 dosing periods each separated by 7 day washout | 24 hours |
| Time of maximum concentration (Tmax), | 24 hour dosing period; 3 dosing periods each separated by 7 day washout | 24 hours |
| λ (terminal disposition rate constant) | 24 hour dosing period; 3 dosing periods each separated by 7 day washout | 24 hours |
| AUCReftmax (Area under the curve to tmax) | 24 hour dosing period; 3 dosing periods each separated by 7 day washout | 24 hours |
| Blood Safety parameters | CBC | 24 hour dosing period; pre dose and 24 hr post dose |
| Blood Safety parameters | electrolytes | 24 hour dosing period; pre dose and 24 hr post dose |
| Blood Safety parameters | glucose | 24 hour dosing period; pre dose and 24 hr post dose |
| Blood Safety parameters | creatinine | 24 hour dosing period; pre dose and 24 hr post dose |
| Blood Safety parameters | AST | 24 hour dosing period; pre dose and 24 hr post dose |
| Blood Safety parameters | ALT | 24 hour dosing period; pre dose and 24 hr post dose |
| Blood Safety parameters | GGT | 24 hour dosing period; pre dose and 24 hr post dose |
| Blood Safety parameters | uric acid | 24 hour dosing period; pre dose and 24 hr post dose |
| Blood Safety parameters | bilirubin | 24 hour dosing period; pre dose and 24 hr post dose |
| Vital Signs | Heart Rate | 24 hour period: pre-dose, 1h, 4h, 6h, 12h, 24h post-dose |
| Vital Signs | Blood Pressure | 24 hour period: pre-dose, 1h, 4h, 6h, 12h, 24h post-dose |