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The addition of dexamethasone (DxaM) to local anesthetic may significantly prolong the duration of a block. The aim of this study is to determine whether this a systemic or local effect.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group I (ISB-P) | Active Comparator | Interscalene block with perineural injection of dexamethasone 0.1 mg/kg |
|
| Group II (ISB-S) | Active Comparator | Interscalene block with systemically injection of dexamethasone 0.1 mg/kg. |
|
| Group III - ISB-C | Active Comparator | Interscalene block without adjuvant. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexamethasone | Drug |
| ||
| Bupivacaine |
| Measure | Description | Time Frame |
|---|---|---|
| Efficacy DxaM Perineural | Duration of motor and sensory block. | One day |
| Measure | Description | Time Frame |
|---|---|---|
| Efficacy of Systemic DxaM | Duration of motor and sensory block | One day |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Anatoly Stav, MD | Contact | 972-4-6304687 | stav@hy.health.gov.il |
| Name | Affiliation | Role |
|---|---|---|
| Anatoly Stav, MD | Hillel Yaffe Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hillel Yaffe Medical Center | Hadera | 38100 | Israel |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34554686 | Derived | Bei T, Liu J, Huang Q, Wu J, Zhao J. Perineural Versus Intravenous Dexamethasone for Brachial Plexus Block: A Systematic Review and Meta-analysis of Randomized Controlled Trials. Pain Physician. 2021 Sep;24(6):E693-E707. |
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| ID | Term |
|---|---|
| D000377 | Agnosia |
| ID | Term |
|---|---|
| D010468 | Perceptual Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D003907 | Dexamethasone |
| D002045 | Bupivacaine |
| ID | Term |
|---|---|
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
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| Drug |
|
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D000072473 |
| Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
| D013259 | Steroids, Fluorinated |
| D000813 | Anilides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000814 | Aniline Compounds |
| D000588 | Amines |