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| Name | Class |
|---|---|
| Malaysian Endocrine and Metabolic Society | OTHER |
| National University of Malaysia | OTHER |
| University of Malaya | OTHER |
| IMU University, Malaysia |
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This will be a population based study looking at the prevalence of thyroid disorders in Malaysia (including hypo- and hyperthyroidism, subclinical hypo- or hyperthyroidism) and its association with different ethnicity and iodine status. The study will also look at genetic susceptibility for autoimmune thyroid disorders in the Malaysian population
General hypotheses:
The prevalence of thyroid disorders in Malaysia is 10% for hypothyroidism and 2% for hyperthyroidism Hypo- and hyperthyroidism is associated with iodine status in our population There are different susceptibility gene for autoimmune thyroid disorder in different ethnicity in our population
This will be a cross-sectional population based study involving Malaysian adults (aged 18 year old and above). Cluster sampling will be used to select respondents that will be representative of the Malaysian population. Selected respondent will be interviewed, anthropometric measurement taken, blood and urine sample taken.
Blood will be analyzed for thyroid function (thyroxine, triiodothyronine and thyroid stimulating hormone), autoantibodies (anti-thyroperoxidase and anti-thyroglobulin). Urine will be analyzed for urinary iodine.
Those diagnosed with autoimmune thyroid disorders with strong family history of thyroid disorders (multiplex multi-generation family involvement) will have their blood sent for whole exome sequencing and linkage analysis done to identify possible susceptible gene for autoimmune thyroid disorders
Respondents detected to have hypo- or hyper- and subclinical hypo- or hyperthyroidism will be referred to their nearest health centre for further evaluation and treatment appropriate for their condition.
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| Measure | Description | Time Frame |
|---|---|---|
| Number of participants with abnormal thyroid function | Overt or subclinical hypothyroidism Overt or subclinical hyperthyroidism | Day 0 |
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants with positive thyroid autoantibodies | Anti-thyroglobulin Anti-thyroperoxidase | Day 0 |
| Number of participants with Iodine deficiency status | Urinary iodine level |
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants with genetic susceptibility to autoimmune thyroid disorders | whole exome sequencing and linkage analysis in families with autoimmune thyroid disorders (multiplex multi-generation involvement) | Day 0 |
Inclusion Criteria:
Exclusion Criteria:
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Adult (aged equal or more than 18 years old ) Malaysian citizen living in Malaysia at the time of sampling
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| Name | Affiliation | Role |
|---|---|---|
| Nor Azmi Kamaruddin, MBBS, MMed | National University of Malaysia | Principal Investigator |
| Norlela Sukor, MMed, Phd | National University of Malaysia | Principal Investigator |
| Norhanita Othman | National University of Malaysia | Principal Investigator |
| Johari Ali | University of Malaya | Principal Investigator |
| Shirenee Vethakkan | University of Malaya | Principal Investigator |
| Siew Kim Kwa | IMU University, Malaysia | Principal Investigator |
| Kuck Meng Chong, MD | Malaysian Endocrine and Metabolic Society | Principal Investigator |
| Lecthuman Ramanathan | Malaysian Endocrine and Metabolic Society | Principal Investigator |
| Hussein Zanariah | Malaysian Endocrine and Metabolic Society | Principal Investigator |
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| ID | Term |
|---|---|
| D007037 | Hypothyroidism |
| D006980 | Hyperthyroidism |
| D006111 | Graves Disease |
| D050031 | Hashimoto Disease |
| D020022 | Genetic Predisposition to Disease |
| ID | Term |
|---|---|
| D013959 | Thyroid Diseases |
| D004700 | Endocrine System Diseases |
| D005094 | Exophthalmos |
| D009916 | Orbital Diseases |
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| OTHER |
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Whole Blood Serum
| Day 0 |
| Nurain Mohd Noor |
| Malaysian Endocrine and Metabolic Society |
| Principal Investigator |
| Norhaliza Mohd Ali | Malaysian Endocrine and Metabolic Society | Principal Investigator |
| Norhayati Yahya | Malaysian Endocrine and Metabolic Society | Principal Investigator |
| Nor Azizah Aziz | Malaysian Endocrine and Metabolic Society | Principal Investigator |
| D005128 |
| Eye Diseases |
| D006042 | Goiter |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
| D013967 | Thyroiditis, Autoimmune |
| D013966 | Thyroiditis |
| D004198 | Disease Susceptibility |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |