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The purpose of this study is to understand the effect of age on language abilities. The investigators aim at investigating the cerebral modifications that take place in normal aging, at the functional an anatomical level.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy adults | 20 young adults aged between 30 and 50 years old. 20 middle aged adults aged between 50 and 70 years old. 20 older adults of 70 years old and more. |
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| Measure | Description | Time Frame |
|---|---|---|
| Blood Oxygen Level Dependent functional MRI | We use 3 functional tasks using block paradigm: Object naming, Verbal generation and semantic judgment, to elicit BOLD response using fMRI in order to compare functional activation patterns between subjects. We also use hypercapnic challenge to elicit BOLD response in order to obtain Cerebral Vascular Reactivity properties of subjects. | There will be a unique MRI measurement for each participant. Group analyses presentation after 1 year. |
| Anatomical MRI | We use Voxel Based Morphometry to compare cortical volume (grey matter) between subjects. We also use tractography Diffusion Tensor Imaging to compare white matter properties between subjects. | There will be a unique MRI measurement for each participant. Group analyses presentation after 1 year. |
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Inclusion Criteria:
Exclusion Criteria:
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60 healthy adults will participate to the study. There will be 3 age groups: 30-50, 50-70, > 70 years. Ech group will contain 20 volunteers.
The volunteers are recruited by means of ads on Laboratory websites and Universities.
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| Name | Affiliation | Role |
|---|---|---|
| Alexandre Krainik, Professor | Neuroradiology department, Grenoble Hospital, INSERM, Grenoble University. | Principal Investigator |
| Monica Baciu, Professor | Laboratory of Psychology and NeuroCognition, CNRS, Grenoble University. | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| IRMaGe facility | Grenoble | 38000 | France |
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