Does Serum Procalcitonin Levels Predict Sepsis in Patients Undergoing Cytoreductive Surgery

A Pilot Study to Determine the Correlation of Serum Procalcitonin Levels and Development of Sepsis in Patients Undergoing Cytoreductive Surgery

Serum procalcitonin levels will be considerably higher, for a longer period of time, in patients who develop sepsis compared to patients with SIRS or those who have an uncomplicated post-surgical recovery. Monitoring of serum procalcitonin trends will allow for an earlier diagnosis of, and initiation of treatment for, sepsis compared to current standard ICU methods.

Inclusion Criteria:

• Female or male person ≥ 18 years of age
• Biopsy proven carcinoma
• Scheduled for cytoreductive surgery, with or without HIPEC
• Eastern Cooperative Oncology Group (ECOG) performance status (PS) = 0, 1, or 2
• Able to give informed consent for protocol participation

Exclusion Criteria:

• Participants are not able to understand or provide written informed consent
• Pre-operative anti-inflammatory medication use within 72 hours of their baseline blood draw
• Pre-operative infection treatment with corticosteroids within 72 hours of their baseline blood draw
• Immunosuppressive illness other than neoplasm
• Pregnant or lactating female